Metabolomic Profile of Patients Undergoing Myocardial Perfusion SPECT
Trial Snapshot
- Phase
- Not Applicable
- Enrollment
- 500
- Locations
- 1
- Primary Endpoint
- Result of myocardial perfusion SPECT: positive or negative for angina, ischemia or perfusion defect.
Study Overview
Brief Summary
The aim of this study is to analyze metabolomic pattern of patients after cardiac stress in order to detect differences based on the type of stress (physical or pharmacological with adenosine agonists) and result of test (positive or negative for ischemia) and to indentify biochemical markers with prognostic value. Clinical data of enrolled patients regarding demographics, cardiovascular risk factors, pretest probability and previous cardiovascular disease will be recorded. Follow up will be at one, three and five years and will be performed by clinical recordings or phone call when necessary. Blood samples of patients undergoing myocardial perfusion SPECT (Single Photon Emission Computed Tomography) are taken before, immediately after stress and 2h after stress. Serum samples will be analyzed by nuclear magnetic resonance in order to know metabolomic profile.
Detailed Description
The aim of this study is to analyze metabolomic pattern of patients after cardiac stress in order to detect differences based on the type of stress (physical or pharmacological with adenosine agonists) and result of test (positive or negative for ischemia) and to indentify biochemical markers with prognostic value. Clinical data of enrolled patients regarding demographics, cardiovascular risk factors, pretest probability and previous cardiovascular disease will be recorded. Follow up will be at one, three and five years and will be performed by clinical recordings or phone call when necessary. Blood samples of patients undergoing myocardial perfusion SPECT are taken before, immediately after stress and 2h after stress. Serum samples will be analyzed by nuclear magnetic resonance in order to know metabolomic profile.
Study Design
- Study Type
- Observational
- Observational Model
- Case Only
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients men or women ≥ 18 years of age
- •Patients with prescription of cardiac perfusion SPECT
Exclusion Criteria
- •Patients with loss of consciousness or confuse, not able to read the information and to sign the writting consent
- •Pregnant women
- •Patients with dobutamine indications in the stress protocol
Outcomes
Primary Outcomes
Result of myocardial perfusion SPECT: positive or negative for angina, ischemia or perfusion defect.
Time Frame: 2 days
Metabolomic profile on NMR (Nuclear Magnetic Resonance ) analysis of serum sample
Time Frame: 6 month
Once all samples analyzed, in order to identify of specific patterns associated to any group (type of test or result of test).
Secondary Outcomes
- Combined end point: Cardiovascular death, Myocardial infarction, Coronary revascularization.(5 years)
- Metabolomic profile on NMR analysis of serum sample(5 years)
- Angina treatment initiation(5 years)