The Flake Study: a study trying to answer the question of whether children with fish allergy can eat flake safely.
- Conditions
- Food AllergyInflammatory and Immune System - Allergies
- Registration Number
- ACTRN12619000111178
- Lead Sponsor
- Dr Sam Mehr
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 35
Inclusion Criteria
Patients aged between 1-18 with a previously diagnosed white fish allergy.
Exclusion Criteria
Physician diagnosed flake allergy.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To ascertain the rate of allergy to flake (gummy shark) in children with a pre-existing white fish allergy. Tolerance of flake is defined as the ability to pass an oral food challenge during the day admission and then continue to eat flake for a two week period following the challenge, <br><br>Passing a food challenge equates to the ability to eat a serving of flake (2 teaspoons) without any allergic symptoms as outlined by the PRACTALL criteria for oral food challenges. <br>[Two weeks after oral food challenge to flake.]
- Secondary Outcome Measures
Name Time Method To evaluate a novel immunoblot assay in the diagnosis of fish allergy.<br><br>The composite outcome of sensitivity and specificity of the immunoblot will be calculated based upon the proportion of children who pass the oral food challenge to flake. This immunoblot uses a immunoflurescence based to measure serum specific IgE reactivity to the flake protein.[12 months following completion of recruitment. ];To evaluate a homogenised fresh skin prick extract for flake in the diagnosis of flake allergy.<br><br>The composite outcome of sensitivity and specificity of the extract will be calculated based upon the proportion of children who pass the oral food challenge to flake. A positive skin test represents a wheal that is greater than or equal to 3mm. or greater than the histamine control (usually greater than 3mm). [12 months following completion of recruitment]