The Swinburne Multivitamin Study: The Effects of Multivitamin Supplementation on mood, stress and brain function in older adults

Phase 4

Completed

• Conditions: Influence of nutrients on mood and stress in healthy older adults; Investigate the role of cardiovascular system in relation to mood and stress; Alternative and Complementary Medicine - Other alternative and complementary medicine; Mental Health - Studies of normal psychology, cognitive function and behaviour; Cardiovascular - Normal development and function of the cardiovascular system

• Registration Number: ACTRN12612000334808
• Lead Sponsor: Swinburne University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-03-22
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Right-handed
-free from psychiatric disorders
-Must not be taking anticoagulants, antidepressants, antipsychotics, anxiolytics, acetylcholine esterase (AChE) inhibitors, anti-Parkinson’s medication, illicit drugs or any cognitive enhancing drugs
-must not be taking any vitamin/mineral or herbal supplements
-non-smoker

Exclusion Criteria

-smokers
-psychiatric disorders
-using vitamins/minerals or herbal supplements
-taking anticoagulants, antidepressants, antipsychotics, anxiolytics, acetylcholine esterase (AChE) inhibitors, anti-Parkinson’s medication, illicit drugs or any cognitive enhancing drugs
-left-handed

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Scores on mood and stress scales. These scales include:<br>-Beck Depression Inventory (BDI)<br>-Beck Anxiety Inventory (BAI)<br>-The Depression, Anxiety, Stress Scale (DASS)<br>-The Perceived Stress Scale (PSS)<br>-The Hospital Depression and Anxiety Scale (HADS)[Before and after 16 weeks of supplementation];patterns of brain electrical activity using the steady state visual evoked potential technique[Before and after 16 weeks of supplementation];Stress/mood using multitasking battery to induce stress and mood questionnaires before and after stress task. The questionnaires include<br>-Bond Lader Visual Analogue Scales<br>-The State/Trait anxiety Index (STAI)<br>-The NASA-task load index (After task only)[Before and after 16 weeks of supplementation]

Secondary Outcome Measures

Name	Time	Method
Blood levels of: homocysteine; c-reactive protein; fibrinogen; lipids; vitamins B6, B12, E, zinc and folate; electrolytes; telomere length.[Before and after 16 weeks of supplementation];Cardiovascular function using transcranial doppler ultrasound and arterial stiffness measure (using sphygmocor system)[Before and after 16 weeks of supplementation]