Angiogenesis With Positron Emission Tomography (PET) Tracer Uptake

Completed

• Conditions: Angiogenesis; Non-Small Cell Lung Cancer

• Registration Number: NCT00671242
• Lead Sponsor: Gunma University

Brief Summary

Purpose: L-\[3-18F\]-α-methyltyrosine (18F-FMT) is an amino-acid tracer for PET. We have conducted a clinicopathologic study to elucidate the correlation of angiogenesis with 18F-FMT and 18F-FDG uptake in the patients with non-small cell lung cancer (NSCLC).

Method: Thirty-seven NSCLC patients were enrolled in this study, and a pair of PET study with 18F-FMT and 18F-FDG was performed. Uptake of PET tracers was evaluated with standardized uptake value. VEGF, CD31, CD34, LAT1 and Ki-67 labeling index of the resected tumors were analyzed by immunohistochemical staining, and correlated with the clinicopathologic variables and the uptake of PET tracers.

Detailed Description

Not available

Study Timeline

• Status Verified: 2008-01
• Study First Submitted: 2008-04-30
• Study First Submitted QC: 2008-05-02
• Last Update Submitted: 2008-05-02
• Study First Posted: 2008-05-05
• Last Update Posted: 2008-05-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Patients who underwent a thoracotomy within 4 weeks after 18F-FMT PET and 18F-FDG PET study
• Histology is non-small cell lung cancer

Exclusion Criteria

• Patient who received neoadjuvant chemotherapy or radiotherapy before surgery
• Patients who have insulin-dependent diabetes

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Gunma University Graduate School of Medicine; 🇯🇵 showa-machi, Maebashi, Gunma, Japan