Multistimulation Group Therapy for Alzheimer's Disease

Not Applicable

Completed

• Conditions: Alzheimer's Disease
• Interventions: Other: Multidimensional stimulation group therapy

• Registration Number: NCT01893398
• Lead Sponsor: Fondazione Don Carlo Gnocchi Onlus

Brief Summary

Our previous findings support the notion that group activity program, based on cognitive stimulation, recreational-occupational activities and physical-psychomotor exercises, can lead to an improvement in behavioral aspects for people with Alzheimer's Disease (AD).

The purpose of this study is to clarify the efficacy of a rehabilitation program in outpatients affected by AD in mild to moderate stages.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-01
• Primary Completion: 2012-12
• Status Verified: 2013-06
• Study First Submitted: 2013-06-24
• Study First Submitted QC: 2013-07-02
• Last Update Submitted: 2013-07-02
• Study First Posted: 2013-07-09
• Last Update Posted: 2013-07-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• diagnosis of possible/probable AD
• mild to moderate stage of AD (MMSE score of 15 - 24)and CDR score of 1-2
• range years in age (65-85) and in school attendance (5-17)
• right handed

Exclusion Criteria

• severe aphasia (Token test score < 20)
• severe auditory and/or visual loss
• overt severe behavioral disturbances (delusions, hallucinations, agitation)
• recent (three month before the MST) introduction or dose modification of the following pharmacological treatments: cholinesterase inhibitor, memantine, antidepressant or antipsychotic drugs.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
rehabilitation (MST) program	Multidimensional stimulation group therapy	The Multidimensional Stimulation group therapy (MST) involved three levels of treatment. The first level was focused on PWA, the second level involved the caregiver, while the third one the dyad PWA-caregiver.

Primary Outcome Measures

Name	Time	Method
Change from baseline in behavioral level	Baseline, 10ws, 22ws	Neuropsychiatric Inventory scale
Change from baseline in cognitive level	Baseline, 10ws, 22 ws	ADAS cog scale
Change from baseline in quality of life	baseline, 10ws,22 ws	SF36 questionaire

Trial Locations

Locations (1)

IRCCS, S Maria Nascente, FOndazione don Gnocchi; 🇮🇹 Milan, Italy