Absorption Kinetics of Polyphenols in Angel's Plant (Angelica Keiskei)
Early Phase 1
Completed
- Conditions
- Oxidative Stress
- Interventions
- Dietary Supplement: Angel's plant (Angelica keiskei)
- Registration Number
- NCT00721643
- Lead Sponsor
- Tufts University
- Brief Summary
The absorption kinetics of polyphenols in angel's plant (Angelica keiskei), which is a dark green leafy vegetable rich in antioxidant nutrients, will be determined in older adults in this pilot study.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
-
Healthy subjects (>60 yr, n=5)
-
subjects with metabolic syndrome (>60 yr, n=5)
-
Subjects who has
- high fasting plasma glucose (>5.6 mmol/L),
- central obesity (waist-hip ratio, >0.9 for men, >0.85 for women)
- either high blood pressure (>130/85 mmHg) or high triacylglycerol (>1.7 mmol/L) will be selected to have metabolic syndrome.
-
normal hematological parameters, normal serum albumin, normal liver function, and normal kidney function
-
no history of smoking or alcoholism.
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Exclusion Criteria
- consume >7 alcoholic drinks/wk
- taking cholesterol medication or hormone replacement
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description 1 Angel's plant (Angelica keiskei) Healthy control, 5g dry power of angel's plant (Angelica keiskei) 2 Angel's plant (Angelica keiskei) Metabolic syndrome, 5g dry powder of angel's plant (Angelica keiskei)
- Primary Outcome Measures
Name Time Method Plasma quercetin 0, 30, 60, 100, 180, 240, 300, 360, 420 & 480 min
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Jean Mayer USDA-Human Nutrition Research Center on Aging at Tufts University
🇺🇸Boston, Massachusetts, United States