Effects of polyphenols extracted from Moringa oleifera leaves to heal split-thickness skin graft donor site wounds

Not Applicable

Conditions: Split-thickness skin graft donor site wound
Skin and Connective Tissue Diseases

Registration Number: ISRCTN17883369

Lead Sponsor: niversité de Goma

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Ongoing

Sex: All

Target Recruitment: 122

Inclusion Criteria

1. Aged 5 to 45 years old
2. Requiring split-thickness skin graft
3. Clinically stable
4. Consented to the study
5. Extent of the donor site wound is less than 10% of the body surface area

Exclusion Criteria

1. Mental illness
2. Patients staying less than 6 months in the city
3. History of hypersensitivity reaction to Moringa oleifera derivatives
4. Immunodeficiency state
5. Pregnancy
6. Age below 5 years or over 45 years
7. Patient suffering from condition that may interfere with wound healing: diabetes, renal or hepatic insufficiency, malignant tumor, hypoalbuminemia (serum albumin <4 g/dL), malnutrition, smoking
8. Does not wish to participate in the study
9. Clinical condition deteriorates during the study
10. Decided to stop participating in the study
11. Discontinuation of treatment
12. Death during the study

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time to complete wound epithelialization assessed using a sterile transparent plastic measuring guide from the Medline brand and the Bates-Jensen Wound Assessment Tool (BWAT) on Days 7, 10, 13, 16, 20, 24 and 28

Secondary Outcome Measures

Name	Time	Method
1. Wound-related background pain measured using visual analogue scale (VAS) and the Wong-Baker Scale on days 7, 10, 13, 16, 20, 24 and 28<br>2. Rate of wound infection measured using culture and sensitivity of wound swab whenever clinical sign of infection is suspected<br>3. Quality of scar measured using the Patient and Observer Scar Assessment Scale (POSAS) at day 28<br>4. The economic value of the dressing material measured using the Incremental Cost-Effectiveness Ratio (ICER) at complete wound epithelialization