Identifying the Neural Correlates of Cognitive Impulsivity in Patients With Tourette Syndrome. "COGIT".
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Tourette Syndrome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
- Enrollment
- 98
- Locations
- 1
- Primary Endpoint
- BOLD signal of functional MRI scan
- Status
- Completed
- Last Updated
- 8 months ago
Overview
Brief Summary
Tourette syndrome (TS) is characterized by the presence of multiple vocal and motor tics. Behavioral disorders associated with TS are common, particularly impulsivity, anti-sociality and socially inappropriate behavior. Specifically, cognitive impulsivity could be the source of these troubles. Its anatomical substrates is based on connections between frontal and striatal areas.
Initially, a battery of behavioral tests measuring different types of impulsivity (motor, cognitive and decision) will be administered on three groups of subjects: TS: 80 patients (40 patients treated and 40 untreated) and 40 healthy volunteers.
Then, investigators will study the fronto-striatal connections in the TS group of 80 patients (40 patients treated and 40 untreated) compared to 40 healthy volunteers using neuroimaging techniques (3T MRI). The techniques used will be functional connectivity study of "resting state" MRI (RS-fMRI) combined with a reconstruction of white matter fibers by diffusion tensor imaging (DTI). Behavioral performance will be correlated with the correlation imaging data to highlight the functional anatomical substrates of impulsivity in patients with TS.
Finally, investigators will look specifically using functional MRI activation, the anatomical and functional substrates of the three types of impulsivity (motor, cognitive and decision-making).
Through this study, investigators hope to elucidate the anatomical and functional bases of cognitive impulsivity in patients with TS and thus lay the basis for more targeted treatments.
Investigators
Eligibility Criteria
Inclusion Criteria
- •For all subjects:
- •≥ about 18 and 65 years old
- •About receiving Social Security or universal health coverage or any equivalent plan
- •About who signed the informed consent
- •For TS patients treated :
- •TS principal diagnosis, based on the DSM-5 criteria
- •Stable pharmacological treatment at least 4 weeks prior to study entry;
- •Possibility of controlling the majority tics of the upper part of the body lying down for at least 10 minutes (frequency tics on YGTSS \<3).
- •For TS patients untreated:
- •TS principal diagnosis, based on the DSM-5 criteria
Exclusion Criteria
- •For all patients TS:
- •Age \<18 years.
- •Presence One of the following diagnoses Axis I DSM-5: schizophrenic disorders or current psychotic episode or in the past, bipolar disorder, current major depressive disorder autism spectrum.
- •Abus Psychotropic substance dependency or a psychotropic substance, including alcohol (except nicotine).
- •Support Regular / chronic drugs and other xenobiotics tropic psychotropic.
- •Support Treatment with benzodiazepines in the 4 months prior to study entry. -Patient Subject to a measure of legal protection (guardianship, curatorship or safeguard justice). -No private freedom by administrative decision or justice.
- •No Unable to consent and are not subject to a protection measure.
- •Participation In other biomedical research or subjected to an exclusion period for another search.
- •Problems General understanding.
- •Weight Of more than 150 kg.
Outcomes
Primary Outcomes
BOLD signal of functional MRI scan
Time Frame: up to one month
behavior performance (percentage of correct responses and reaction time)
Time Frame: up to one month