Effects of low-carbohydrate diet on preferential abdominal fat loss for 6 months in type 2 diabetes
- Conditions
- Type 2 diabetes
- Registration Number
- JPRN-UMIN000003425
- Lead Sponsor
- Himoto Clinic
- Brief Summary
The patients showed good compliance with the LCD (1812 +/- 375 kcal/day, % carbo-hydrate:fat:protein = 35:40:19 for men; 1706 +/- 323 kcal/day, % carbohydrate:fat:protein = 41:36:21 for women). Significant decreases (P = 0.05) in BMI and HbA1c levels were observed, along with an increase in HDL-C (P = 0.021) in men and a decrease in LDL-C (P = 0.001) in women. VAT (21.6 cm2, P < 0.001 in men;19.6 cm2;, P < 0.001 in women) and SAT (13.5 cm2, P = 0.004 in men;19.1 cm2, P = 0.003 in women) significantly decreased. The loss of VAT (%deltaVAT) was greater than that of SAT (%deltaSAT) in women (P = 0.022). A similar but not significant predominance of VAT loss was detected in men (P = 0.111). In women, the %deltaSAT significantly correlated with changes in FBG (deltaFBG) (r = 0.417) and HDL-C (deltaHDL) (r = 0.720), as was %deltaVAT with changes in triglyceride (deltaTG) (r = 0.591).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 50
Not provided
Patients with serum creatinine levels > 1.5 mg/dl, severe diabetes complications (proliferative retinopathy, symptomatic neuropathy or diabetic foot), ketoacidosis, soft drink ketosis, cancer, severe heart failure and liver cirrhosis.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Body mass index, visceral fat and subcutaneouse fat measured by CT, insulin, fasting blood glucose, HbA1c, total energy intake,%carbohydrate, %protein and %fat assessed by dietary food records(at baseline,after 3-month, after6- month).
- Secondary Outcome Measures
Name Time Method blood pressure, serum lipid profiles, albumin-creatinine ratio of spot urine(at baseline,after 3-month, after6- month).