Susceptibility of Cardiorespiratory Responses to Ozone During Cycling Exercise
- Conditions
- Ozone Exposure During Rest and Exercise
- Registration Number
- NCT05473000
- Lead Sponsor
- University of British Columbia
- Brief Summary
Ground level ozone (O3) is a common airborne pollutant that is well recognized to cause negative respiratory symptoms and impair pulmonary function. The proposed study aims to have participants perform submaximal and maximal cycling exercise protocols exposed to both O3 and room air in a crossover design to evaluate how ventilatory patterns, pulmonary function, development of symptoms, and cycling performance are impacted by O3 exposure. Additionally, the investigators look to compare responses between O3 at rest and during exercise to predict which subjects may be most susceptible to adverse response, as considerable interindividual variability exists.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 20
- Healthy males between the age of 18 and 50
- Currently training and/or competing in endurance sport
- VO2max >60 ml/kg/min
- Able to communicate sufficiently using the English language
- History of smoking
- Upper respiratory tract infection within the last 4 weeks
- Presence of any chronic respiratory disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Time-to-exhaustion on Maximal Cycling Bout From the beginning of the maximal constant work-rate cycling bout until volitional exhaustion occurs (roughly 1-5 minutes) Measurement of time (in seconds) to volitional exhaustion on a constant work-rate cycling trial at 110% of previously determined maximal power output.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of British Columbia
🇨🇦Vancouver, British Columbia, Canada
University of British Columbia🇨🇦Vancouver, British Columbia, Canada