Scrub Typhus Infection Induced Cardiovascular Disease

Active, not recruiting

• Conditions: Scrub Typhus; Cardiovascular Complication
• Interventions: Other: No intervention

• Registration Number: NCT03274869
• Lead Sponsor: Eulji University Hospital

Brief Summary

Scrub typhus infection has been considered as seasonal and endemic infectious disorder with benign feature. However, the increasing mortality rate of scrub typhus has been recently reported in Southeast Asia and cause of death could be a fetal complicating cardiovascular disease. Therefore, the association and predictors for scrub typhus induced cardiovascular disease should be investigated to provide a timely and appropriate diagnosis and to reduce the mortality rate of complicated scrub typhus infection. Therefore, investigators prospectively investigate the association and predictors of cardiovascular disease in the participants with scrub typhus infection.

Detailed Description

Scrub typhus is a zoonotic disease caused by Orientia tsutsugamushi confined to East Asia including South Korea. It is characterized by fever, headache, rash, and eschar and the majority of patients without complications can recover with an early diagnosis and proper management with antibiotics. However, the increasing mortality rate of scrub typhus has been recently reported in Southeast Asia. Severe complications can be manifested by respiratory distress syndrome, renal failure, hepatic failure, and cardiovascular disease. Especially, cardiovascular complications can lead to cardiogenic shock and sudden cardiac arrest. Therefore, the association and predictors for scrub typhus induced cardiovascular disease should be investigated to provide a timely and appropriate diagnosis and to reduce the mortality rate of complicated scrub typhus infection. Therefore, investigators prospectively investigate the association and predictors of cardiovascular disease in the participants with scrub typhus infection admitted to 3rd referral centers in South Korea.

Study Timeline

• Study First Submitted: 2017-09-03
• Study First Submitted QC: 2017-09-06
• Study First Posted: 2017-09-07
• Study Start: 2022-09-01
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-20
• Last Update Posted: 2025-03-24
• Primary Completion: 2026-09-01
• Study Completion: 2027-08-30

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• any participants with scrub typhus infection

Exclusion Criteria

• patients under age of 18
• pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Scrub typhus without cardiovascular complications	No intervention	Any participants with the scrub typhus infection without cardiovascular complication will be enrolled as a positive control group during admission and clinically followed by 1 year after discharge
Scrub typhus with cardiovascular complication	No intervention	Any participants with the scrub typhus infection with cardiovascular complication will be enrolled as a comparison group during admission and clinically followed by 1 year after discharge

Primary Outcome Measures

Name	Time	Method
Cardiovascular Mortality	one year	Cardiovascular death including sudden cardiac death

Secondary Outcome Measures

Name	Time	Method
Cardiovascular Complications	one year	Atrial Fibrillation, Acute Heart Failure including acute myocarditis and Ischemic Heart Dease

Trial Locations

Locations (2)

Chung-Nam University Hospital; 🇰🇷 Daejeon, Chung Chung Do, Korea, Republic of

Chung-Buk University Hospital; 🇰🇷 Chungju, Chung Chung Do, Korea, Republic of