Use of Hyperbaric Oxygen Therapy for the Treatment of Crush Injuries

NYU Langone Health1 site in 1 countrySeptember 1, 2021

ConditionsCrush Injury

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Crush Injury
Sponsor: NYU Langone Health
Locations: 1
Primary Endpoint: healing measured by percentage of skin necrosis using a Bilateral Perfusion Index (BPI; TCOM of the affected limb/TCOM of the nonaffected limb).
Status: Withdrawn
Last Updated: 3 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to determine whether using hyperbaric oxygen (HBO) improves wound healing for patients who have a crush injury. The comparison of the prospective intervention group to the retrospective matched cohort aims to show that HBO can improve wound healing and decrease poor outcomes for patients with crush injuries. The information gained from this small study will serve as a basis for a follow-up prospective, randomized control trial to further delineate the role of HBO in a larger patient population.

Registry

clinicaltrials.gov

Start Date

September 1, 2021

End Date

September 2023

Last Updated

3 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

NYU Langone Health

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Presenting to NYU Winthrop Hospital with a crush injury of the extremity, including appendages, up to 14 days post injury.
•No contraindication to hyperbaric oxygen therapy.
•Able and willing to sign informed consent.

Exclusion Criteria

•Critically-ill patient requiring intubation or pressor support.
•Crush injury isolated to the distal phalanx (Tuft fracture).
•Absolute contraindication to hyperbaric oxygen therapy (untreated pneumothorax). Relative contraindications (uncontrolled congestive heart failure, uncontrolled seizure disorder, pulmonary disease, claustrophobia) will be assessed by the treating physician.
•Unable or unwilling to sign informed consent.