Long-term of Remote Ischemic Preconditioning in Patients With Mild Hypertension
- Conditions
- Hypertension
- Interventions
- Other: Antihypertensive drugsOther: remote ischemic preconditioning（RIPC）Behavioral: lifestyle intervention
- Registration Number
- NCT04753840
- Lead Sponsor
- Henan Institute of Cardiovascular Epidemiology
- Brief Summary
According to the latest survey data of China hypertension annual meeting, there are about 300 million patients with hypertension in China, with 10 million new cases of hypertension each year, and there is an obvious trend of younger people. In particular, young and middle-aged people are in a state of mild hypertension for a long time, which causes great pressure on health and medical treatment. At present, the main clinical measures for mild hypertension are to change their eating habits, quit smoking and alcohol, exercise and other lifestyle changes, as well as drug control. For most patients with mild hypertension, drug control is not the best choice. It has been reported that remote ischemic preconditioning (RIPC) may play an effective role in reducing blood pressure .The purpose of this study was to investigate the extent of long-term application of RIPC to reduce blood pressure in patients with mild hypertension.
- Detailed Description
A total of 200 patients with mild hypertension were enrolled in this study, using the method of open label and parallel grouping; 100 cases in the experimental group and 100 cases in the control group, The experimental group was divided into life intervention + drug group and life intervention + ripc group, with 50 patients in each group. The results of 24-hour ambulatory blood pressure monitoring (ABPM) of the three groups were observed before and 3 months after use, including HR, pulse pressure, 24-hour systolic blood pressure, 24-hour diastolic blood pressure, daytime systolic blood pressure, daytime diastolic blood pressure, nighttime systolic blood pressure and nighttime diastolic blood pressure. The changes of renalase, catecholamine, renin, angiotensin - Ⅱ, aldosterone, RhoA kinase, no, adenosine and bradykinin were observed.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 90
- Diagnosed patients with mild hypertension (SBP: 140~159mmHg; DBP: 90~99mmHg)
- Cannot tolerate RIPC
- Non-essential hypertension
- patients who have uncontrolled severe arrhythmia, diabetes, electrolyte disturbance
- patients who have severe organic diseases such acute myocardial infarction, cardiac insufficiency, abnormal renal function, etc.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Experimental A: Drug group+lifestyle intervention Antihypertensive drugs Experimental group A used only one antihypertensive drug (ACEI / ARB, beta blocker, calcium channel blocker, diuretic, etc.) plus lifestyle intervention to control blood pressure. Experimental B: RIPC group+lifestyle intervention remote ischemic preconditioning（RIPC） The experimental group B received ripc treatment of upper limbs every day plus lifestyle intervention until the end of the follow-up. The treatment time was 40 minutes per day, 10 minutes as a cycle (cuff inflated to 200 mmHg and maintained for 5 minutes, then deflated for 5 minutes to start the next cycle), a total of 4 cycles. Experimental c: lifestyle intervention lifestyle intervention The control group take lifestyle intervention to control blood pressure, such as changing dietary habits, smoking cessation and alcohol restriction, exercise and so on. Experimental A: Drug group+lifestyle intervention lifestyle intervention Experimental group A used only one antihypertensive drug (ACEI / ARB, beta blocker, calcium channel blocker, diuretic, etc.) plus lifestyle intervention to control blood pressure. Experimental B: RIPC group+lifestyle intervention lifestyle intervention The experimental group B received ripc treatment of upper limbs every day plus lifestyle intervention until the end of the follow-up. The treatment time was 40 minutes per day, 10 minutes as a cycle (cuff inflated to 200 mmHg and maintained for 5 minutes, then deflated for 5 minutes to start the next cycle), a total of 4 cycles.
- Primary Outcome Measures
Name Time Method Mean diastolic blood pressure 3 months 24-hour Mean diastolic blood pressure measured by Ambulatory blood pressure monitoring
Mean systolic blood pressure 3 months 24-hour Mean systolic blood pressure measured by Ambulatory blood pressure monitoring
- Secondary Outcome Measures
Name Time Method Concentration of Renalase 3 months blood renalase concentration
Concentration of adenosine 3 months blood adenosine concentration
Concentration of renin 3 months blood renin concentration
Concentration of catecholamine 3 months Blood catecholamine concentration
Concentration of bradykinin 3 months blood bradykinin concentration
Trial Locations
- Locations (1)
Fuwai central China Cardiovascular hospital
🇨🇳Zhengzhou, Henan, China