Systemic Cross-talk Between Brain, Gut, and Peripheral Tissues in Glucose Homeostasis: Effects of Exercise Training

Not Applicable

Completed

• Conditions: Obesity; Insulin Resistance; Exercise Training; Type2 Diabetes
• Interventions: Behavioral: Exercise training

• Registration Number: NCT03730610
• Lead Sponsor: University of Turku

Brief Summary

Obesity and insulin resistance are worldwide epidemic and taking a major public health toll. Obesity also increases the risk for cognitive impairment which is also an increasing medical, societal, and economic challenge. The ultimate goal of this proposal is to develop a statistical model to assess systemic cross-talk between brain, peripheral tissues, gut microbiota and glucose metabolism. Integrated with exercise training intervention the results will be utilized to provide disease risk profiling and personalized predictions of exercise training as a drug free treatment for insulin resistance and type 2 diabetes.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-10-31
• Study First Submitted QC: 2018-11-02
• Study First Posted: 2018-11-05
• Study Start: 2019-01-30
• Primary Completion: 2021-10-31
• Study Completion: 2021-10-31
• Status Verified: 2022-02
• Last Update Submitted: 2022-02-25
• Last Update Posted: 2022-03-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• monozygotic twins
• body mass index (BMI) difference ≥ 2 kg/m2 and/or type 2 diabetes
• At least one co-twin is overweight (BMI > 25 kg/m2)

Exclusion Criteria

• BMI > 60 kg/m2
• body weight > 170 kg
• waist circumference > 150 cm
• mental disorder or poor compliance
• eating disorder or excessive use of alcohol
• active ulcus disease
• diabetes requiring insulin treatment or fasting glucose > 10 mmol/l
• pregnancy
• past dose of radiation
• claustrophobia
• presence of ferromagnetic objects that would make MRI contraindicated

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Exercise intervention	Exercise training	Six months of exercise training

Primary Outcome Measures

Name	Time	Method
Effects of exercise training - brain glucose uptake	The change from baseline to 6 months	Brain glucose uptake (micromol/100g/min) is measured with positron emission tomography (PET) with \[18F\]-labelled fluoro-deoxy-glucose (FDG) tracer.
Effects of exercise training - brain inflammation	The change from baseline to 6 months	Brain inflammation (dimensionless; standistibution volume ratio) is measured with positron emission tomography (PET) with PK11195 tracer

Secondary Outcome Measures

Name	Time	Method
Effects of exercise training - adipose tissue glucose uptake	The change from baseline to 6 months	Adipose tissue glucose uptake (micromol/100g/min) is measured with positron emission tomography (PET) with \[18F\]-labelled fluoro-deoxy-glucose (FDG) tracer
Effects of exercise training - liver glucose uptake	The change from baseline to 6 months	Liver glucose uptake (micromol/100g/min) is measured with positron emission tomography (PET) with \[18F\]-labelled fluoro-deoxy-glucose (FDG) tracer
Effects of exercise training - whole-body insulin sensitivity	The change from baseline to 6 months	Whole-body insulin sensitivity (M-value; micromol/100g/min) during the hyperinsulinemic euglycemic clamp
Effects of exercise training - ectopic fat	The change from baseline to 6 months	Ectopic fat content (%) is measured using magnetic resonance spectroscopy (MRS)

Trial Locations

Locations (1)

University of Turku; 🇫🇮 Turku, Finland