Modelling Systemic Cross-talk Between Brain, Gut, and Peripheral Tissues in Glucose Homeostasis: Exercise Training and Public Health
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Obesity
- Sponsor
- University of Turku
- Enrollment
- 24
- Locations
- 1
- Primary Endpoint
- Effects of exercise training - brain glucose uptake
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Obesity and insulin resistance are worldwide epidemic and taking a major public health toll. Obesity also increases the risk for cognitive impairment which is also an increasing medical, societal, and economic challenge. The ultimate goal of this proposal is to develop a statistical model to assess systemic cross-talk between brain, peripheral tissues, gut microbiota and glucose metabolism. Integrated with exercise training intervention the results will be utilized to provide disease risk profiling and personalized predictions of exercise training as a drug free treatment for insulin resistance and type 2 diabetes.
Investigators
Jarna Hannukainen
Adjunct Professor
University of Turku
Eligibility Criteria
Inclusion Criteria
- •monozygotic twins
- •body mass index (BMI) difference ≥ 2 kg/m2 and/or type 2 diabetes
- •At least one co-twin is overweight (BMI \> 25 kg/m2)
Exclusion Criteria
- •BMI \> 60 kg/m2
- •body weight \> 170 kg
- •waist circumference \> 150 cm
- •mental disorder or poor compliance
- •eating disorder or excessive use of alcohol
- •active ulcus disease
- •diabetes requiring insulin treatment or fasting glucose \> 10 mmol/l
- •pregnancy
- •past dose of radiation
- •claustrophobia
Outcomes
Primary Outcomes
Effects of exercise training - brain glucose uptake
Time Frame: The change from baseline to 6 months
Brain glucose uptake (micromol/100g/min) is measured with positron emission tomography (PET) with \[18F\]-labelled fluoro-deoxy-glucose (FDG) tracer.
Effects of exercise training - brain inflammation
Time Frame: The change from baseline to 6 months
Brain inflammation (dimensionless; standistibution volume ratio) is measured with positron emission tomography (PET) with PK11195 tracer
Secondary Outcomes
- Effects of exercise training - adipose tissue glucose uptake(The change from baseline to 6 months)
- Effects of exercise training - liver glucose uptake(The change from baseline to 6 months)
- Effects of exercise training - whole-body insulin sensitivity(The change from baseline to 6 months)
- Effects of exercise training - ectopic fat(The change from baseline to 6 months)