ISRCTN13704604已完成未知
A randomised controlled trial to compare the safety and effectiveness of doxycycline (200 mg/day) with prednisolone (0.5 mg/kg/day) for initial treatment of bullous pemphigoid
niversity of Nottingham (UK)0 个研究点目标入组 256 人开始时间: 2008年11月12日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 256
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Both males and females, aged at least 18 years old
- •2. Able to provide written informed consent
- •3. Clinical features consistent with bullous pemphigoid
- •4. Either a direct or indirect (serum) immuno-fluorescence (linear IgG/C3 at epidermal basement membrane zone) positive for bullous pemphigoid
- •5. At least three significant blisters spread over two or more body sites that have appeared in the week prior to study enrolment
- •6. Free of blisters and any treatment for previous episodes of bullous pemphigoid for at least one year
排除标准
- •1. Received any of the study medications or other recognised systemic medications for the treatment of this episode of bullous pemphigoid prior to study entry. Prior topical treatment for this episode is permitted.
- •2. Recent administration of a live virus vaccine
- •3. Mainly or entirely mucosal pemphigoid
- •4. Known allergy to tetracyclines
- •5. Presence of any condition which precludes the use of either of the study drugs
- •6. Women of childbearing potential who are not taking adequate contraception or who are pregnant, plan to become pregnant during the study duration or lactating
- •7. Has active cancer (apart from basal cell carcinoma and Bowen's disease)
- •8. Has any other condition which would, in the Investigator's opinion, deem the patient unsuitable for participation in the study
- •9. Taking part in any other intervention study
研究者
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