The Impacts of Theta-burst Stimulation Over Posterior Superior Temporal Sulcus on Children and Adolescents With Autism Spectrum Disorder
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 试验地点
- 2
- 主要终点
- Changes of Total Scores of Repetitive Behavior Scale-Revised
研究概览
简要总结
The investigator would like to investigate the impact of theta-burst stimulation over posterior superior temporal sulcus in children and adolescents with autism spectrum disorder
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 7 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •autism spectrum disorder, confirmed by ADOS
排除标准
- •current and past systemic disease
- •current and past major psychiatric disorders including schizophrenia, bipolar affective disorder and major depressive disorder
- •current and past brain injuries
- •intelligence < 70
- •seizure history
结局指标
主要结局
Changes of Total Scores of Repetitive Behavior Scale-Revised
时间窗: baseline; during TBS (4 weeks after baseline); post TBS (8 weeks after baseline); One month follow up (4 weeks after post TBS)
RBS-R is a questionnaire that focuses on repetitive behavior. The score range from 0-129. The lower scores stand for lower repetitive behavior.
Changes of Total Scores of Social Responsiveness Scale
时间窗: baseline; during TBS (4 weeks after baseline); post TBS (8 weeks after baseline); One month follow up (4 weeks after post TBS)
Social Responsiveness Scale can measure the autism clinical severity with the range from 65-260. The lower scores stand for better social responsiveness.
次要结局
- Functional MRI (Biological Motion Task)(baseline; during TBS (4 weeks after baseline); post TBS (8 weeks after baseline))
- Changes in Accuracy of Eyes Task(baseline; during TBS (4 weeks after baseline); post TBS (8 weeks after baseline); One month follow up (4 weeks after post TBS))
- Changes in Accuracy of Frith-Happe Animation(baseline; during TBS (4 weeks after baseline); post TBS (8 weeks after baseline); One month follow up (4 weeks after post TBS))
- Resting State fMRI(baseline; during TBS (4 weeks after baseline); post TBS (8 weeks after baseline))
- Diffusion Tensor Imaging(baseline; during TBS (4 weeks after baseline); post TBS (8 weeks after baseline))