Pathophysiology of Acute Atrial fibrillation in Obstructive Sleep Apnea

Completed

• Conditions: atrial arrhythmia; heart rhythm disturbance; 10007521; 10040998; 10038716

• Registration Number: NL-OMON54128
• Lead Sponsor: Catharina-ziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 9 September 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 225

Inclusion Criteria

Paroxysmal AF, with symptoms occurring at least once per week
STOP-BANG score >=5 or STOP-BANG >=4 and typical nocturnal onset of AF
Ability to provide informed consent

Exclusion Criteria

Current (not prior) adequate (i.e. residual AHI <5) treatment with CPAP or MRA
Reversible cause of AF (e.g. hyperthyroidism)
Severe lung disease (COPD Gold IV, pulmonary fibrosis, lobectomy)
Severe esophageal disease (malignancy, stricture, esophagectomy)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Identification of prognostic factors for the initiation of atrial fibrillation<br /><br>in relation to obstructive sleep apnea related pathophysiological mechanisms. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Validation of nonobtrusive photoplethysmography and diafragm electromyography<br /><br>measurements as surrogate for invasive esophageal pressure measurement. </p><br>