Resolution of Allergic Inflammation: Identification and Kinetics of Specific Lipid Mediators During Nasal Allergen Challenge
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Clinical nasal score and measurement of mediators in biological fluids
研究概览
简要总结
After an allergen challenge, the allergic inflammatory response disappears spontaneously. The initiation of the resolution of the inflammatory response is now recognized as a dynamic process, involving active biochemical programs that enable inflamed tissues to return to homeostasis. Recent data established key roles of different specific lipid mediators in the endogenous counter-regulation of inflammation and activation of resolution. Only little is known about kinetics of these specialized pro-resolving lipid mediators during acute allergic inflammation. Therefore, the primary propose of our study is to characterize the temporal evolution of cellular inflammation and specific lipid mediators after allergen challenge.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Eligibility criteria:
- •Inclusion Criteria
- •Allergic rhinitis during the grass pollen season with or without asthma, with at least one of the following symptoms: nasal congestion, itching, rhinorrhea, sneezing
- •Grass pollen sensitization determined by a positive skin prick test and / or presence of specific IgEs to a grass pollen allergen extract
排除标准
- •Specific immunotherapy with grass allergens or other respiratory allergen for inclusion.
- •Current exhibition to another clinically relevant respiratory allergen
研究组 & 干预措施
Grass pollen allergen extract
干预措施: Grass pollen allergen extract (Other)
measurement of mediators in biological fluids
干预措施: placebo (Other)
结局指标
主要结局
Clinical nasal score and measurement of mediators in biological fluids
时间窗: Measurement of mediators in biological fluids during 72 h after nasal allergen challenge
Clinical nasal score and measurement of mediators in biological fluids.
时间窗: Measurement and indentification of specific lipid mediators during nasal allergen challenge
次要结局
未报告次要终点