Pathogenesis of Primary Spontaneous Pneumothorax

• Conditions: Pneumothorax
• Interventions: Procedure: Thoracoscopic bullectomy

• Registration Number: NCT01135004
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

Primary spontaneous pneumothorax most commonly occurs in young, tall, lean males. The estimated recurrence rate is 23-50% after the first episode and increases to 60% after the second pneumothorax. The pathogenesis of this benign disease remains unclear. Generally, rupture of the emphysematous change or blebs in the apex of the lung is considered as the cause of pneumothorax. The main purpose of this study is to investigate the molecular pathogenesis of blebs formation or emphysematous change of the lung in these young, healthy patients.

Detailed Description

Primary spontaneous pneumothorax most commonly occurs in young, tall, lean males. The estimated recurrence rate is 23-50% after the first episode and increases to 60% after the second pneumothorax. The pathogenesis of this benign disease remains unclear. Generally, rupture of the emphysematous change or blebs in the apex of the lung is considered as the cause of pneumothorax. The main purpose of this study is to investigate the molecular pathogenesis of blebs formation or emphysematous change of the lung in these young, healthy patients. The blebs resected from the pneumothorax patients will be used for RNA and protein levels analyses. The adjacent normal lung tissue will be used as a control for comparison.

Study Timeline

• Status Verified: 2010-03
• Study Start: 2010-03
• Study First Submitted: 2010-05-30
• Study First Submitted QC: 2010-06-01
• Last Update Submitted: 2010-06-01
• Study First Posted: 2010-06-02
• Last Update Posted: 2010-06-02
• Primary Completion: 2012-02
• Study Completion: 2013-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Age between 14 and 40 years
• Spontaneous pneumothorax
• Underwent bullectomy of the lung

Read More

Exclusion Criteria

• With underlying lung disease

Read More

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Pneumothorax patients	Thoracoscopic bullectomy	Primary spontaneous pneumothorax patients undergoing thoracoscopic bullectomy

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan