Normal Values for Myocardial Left Atrial Strain

• Conditions: Atrial Function

• Registration Number: NCT03874624
• Lead Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Brief Summary

Transversal retrospective and unicentric study. The investigators sought to determine the normal values for two-dimensional myocardial left atrial strain for the cardiology ultrasound system available in their centre (Philips EPIQ ultrasound machine and 10.8.5 QLAB cardiac analysis software). Studies performed in their department which meet the criteria for an adequate strain analysis will be retrospectively reviewed.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-02-22
• Status Verified: 2019-03
• Study First Submitted: 2019-03-01
• Study First Submitted QC: 2019-03-12
• Last Update Submitted: 2019-03-12
• Study First Posted: 2019-03-14
• Last Update Posted: 2019-03-14
• Primary Completion: 2019-05-31
• Study Completion: 2019-05-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 43

Inclusion Criteria

• No history of cardiopathy / pneumopathy.
• No history of hypertension or mellitus diabetes.

Exclusion Criteria

• Pregnancy.
• Athletes.
• Body mass index < 16 or => 30 kg/m2.
• Previous treatment with cardiotoxic chemotherapy.
• Dilated left ventricle (telediastolic diameter index > 30 mm/m2).
• Interventricular septal thickness => 12 mm.
• Dilated left atria (volume => 31 ml/m2).
• Systolic pulmonary pressure => 35 mmHg.
• Moderate or severe valvulopathy.
• Incomplete or suboptimal left atrial visualization.
• Frame rate < 50 fps.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Global peak reservoir strain.	Through study completion, an average of 4 months.	Percentage of peak reservoir strain for 4-, 2- and 3-chambers will be combined to report percentage of global peak reservoir strain.
Global pump strain.	Through study completion, an average of 4 months.	Percentage of pump reservoir strain for 4-, 2- and 3-chambers will be combined to report percentage of global pump strain.
Global conductance strain.	Through study completion, an average of 4 months.	Measured as the difference between global reservoir strain and gobal pump strain.
Global reservoir strain rate.	Through study completion, an average of 4 months.	Reservoir strain rate for 4-, 2- and 3-chambers will be combined to report global reservoir strain rate.
Global conductance strain rate.	Through study completion, an average of 4 months.	Conductance strain rate for 4-, 2- and 3-chambers will be combined to report global conductance strain rate.
Global pump strain rate.	Through study completion, an average of 4 months.	Pump strain rate for 4-, 2- and 3-chambers will be combined to report global pump strain rate.

Secondary Outcome Measures

Name	Time	Method
Left ventricular telediastolic volume	Through study completion, an average of 4 months.	Measured by Simpson's method
Left ventricular dimensions	Through study completion, an average of 4 months.	Assessed by the following parameters: telediastolic diameter, interventricular septal thickness, posterior wall thickness (in mm)
E/A ratio	Through study completion, an average of 4 months.	Transmitral flow profile.
E/e' ratio	Through study completion, an average of 4 months.	Tissue doppler derived parameter.
Sex	Through study completion, an average of 4 months.	male or female
Weight in kilograms	Through study completion, an average of 4 months.
Age in years	Through study completion, an average of 4 months.
Height in meters	Through study completion, an average of 4 months.
Left atrial volume	Through study completion, an average of 4 months.	Measured by biplanar volumetric method
Left ventricular ejection fraction	Through study completion, an average of 4 months.	Measured by biplanar Simpson's method

Trial Locations

Locations (1)

Hospital de la Santa Creu i Sant Pau; 🇪🇸 Barcelona, Spain