The Diagnostic Value of Contrast-enhanced Ultrasound in Acute Kidney Injury in ICU

Not yet recruiting

• Conditions: Acute Kidney Injury; Ultrasound; Intensive Care Unit
• Interventions: Diagnostic Test: Contrast-enhanced Ultrasound

• Registration Number: NCT06353659
• Lead Sponsor: Peking University Third Hospital

Brief Summary

The goal of this observational study is to quantitatively assess the renal microcirculation changes by contrast-enhanced ultrasound (CEUS) and to obtain systemic hemodynamic information by ultrasound Doppler at the same time, to analyze the relationship between renal microcirculation changes and systemic hemodynamic changes, and to explore the diagnostic value of CEUS in critically ill acute kidney injury.

Detailed Description

The main questions it aims to answer are:

1. To explore the quantitative parameters of contrast-enhanced ultrasound which can reflect the changes of renal microcirculation。

2. To explore the relationship between renal microcirculation and systemic hemodynamics。

3. To explore the value of quantitative evaluation of renal microcirculation changes by contrast-enhanced ultrasound in the diagnosis of acute kidney injury

Study Timeline

• Study First Submitted: 2024-03-05
• Status Verified: 2024-04
• Study First Submitted QC: 2024-04-07
• Last Update Submitted: 2024-04-07
• Study First Posted: 2024-04-09
• Last Update Posted: 2024-04-09
• Study Start: 2024-04-15
• Primary Completion: 2025-06-30
• Study Completion: 2026-06-30

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Age>18 years old
• First admission to ICU < 24h after admission and expected ICU stay ≥48 hours
• Acute kidney injury risk factors (KDIGO 2012)
• Contrast-enhanced ultrasound

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Exclusion Criteria

• Known severe chronic kidney disease (CKD≥ stage 4) or undergoing hemodialysis treatment
• Kidney transplantation or renal malignancy
• Terminal stage of malignant tumor
• Pregnancy
• Renal artery stenosis or renal vein thrombosis
• The quality of CEUS images is poor, and quantitative analysis cannot be performed

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with acute kidney injury (AKI)	Contrast-enhanced Ultrasound	Patient diagnosed with AKI according to kidney disease improving global outcomes (KDIGO) 2012 criteria
Patients without AKI	Contrast-enhanced Ultrasound	Patient diagnosed without AKI according to kidney disease improving global outcomes (KDIGO) 2012 criteria

Primary Outcome Measures

Name	Time	Method
Acute kidney injury (according to KDIGO 2012 criteria)	Through study completion, an average of 7 days	Acute kidney injury occur or not