Evaluation of the Effectiveness of Predicting the Integrity of Interlobar Fissures Based on Chest Image AI Technology

Not yet recruiting

• Conditions: Chronic Obstructive Pulmonary Disease
• Interventions: Other: artificial analysis of chest image; Procedure: imported Chartis detection system; Other: Emphysema quantitative analysis software based on chest image AI technology

• Registration Number: NCT05774730
• Lead Sponsor: China-Japan Friendship Hospital

Brief Summary

The goal of observational study is to evaluate effectiveness of predicting the integrity of interlobar fissures based on chest image AI technology in patients with Chronic Obstructive Pulmonary Disease who will undergo lung volume reduction surgery with endobronchial valve implantation. The main question it aims to answer is: evaluation of the effectiveness of predicting the integrity of interlobar fissures based on chest image AI technology.

Participants will be evaluated by lung CT (quantitative analysis based on chest image AI technology and artificial analysis) and imported Chartis detection system.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-03
• Study First Submitted: 2023-03-06
• Study First Submitted QC: 2023-03-16
• Last Update Submitted: 2023-03-17
• Study First Posted: 2023-03-20
• Last Update Posted: 2023-03-21
• Study Start: 2023-03-26
• Primary Completion: 2024-12-31
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Patients with chronic obstructive pulmonary disease who meet the GOLD diagnostic criteria
• FEV1 ≤ 45% pred and FEV1/FVC<70%
• TLC>100% pred and RV>175% pred
• CAT≥18
• >50% of emphysema destruction
• Smoking prohibition>6 months
• Sign the informed consent form

Exclusion Criteria

• PaCO2>8.0 kPa, or PaO2<6.0 kPa
• 6-minute walking test<160m
• Obvious chronic bronchitis, bronchiectasis or other infectious lung diseases
• Three hospitalizations due to pulmonary infection in the past 12 months before the baseline assessment
• Previous lobectomy, LVRS or lung transplantation
• LVEF<45% and or RVSP>50mmHg
• Anticoagulant therapy that cannot be stopped before surgery
• The patient has obvious immune deficiency
• Participated in other lung drug studies within 30 days before this study
• Pulmonary nodules requiring intervention
• Any disease or condition that interferes with the completion of the initial or subsequent assessment

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
artificial analysis	artificial analysis of chest image	-
imported Chartis detection system	imported Chartis detection system	-
Emphysema quantitative analysis softwarebased on chest image AI technology	Emphysema quantitative analysis software based on chest image AI technology	-

Primary Outcome Measures

Name	Time	Method
Therapeutic effect of lung volume reduction surgery	6 months after bronchoscopic valve lung volume reduction	Lung CT
the integrity of interlobar fissure	Before bronchoscopic valve lung volume reduction	Emphysema quantitative analysis softwarebased on chest image AI technology, artificial analysis and imported Chartis detection system