Effect of Short-term Oxygen During CPET in COPD
Phase 2
Completed
- Conditions
- Chronic Obstructive Pulmonary Disease
- Interventions
- Procedure: Oxygen application
- Registration Number
- NCT03196089
- Lead Sponsor
- University of Zurich
- Brief Summary
In a randomized, sham-controlled trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with chronic obstructive pulmonary disease.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- diagnosis of chronic obstructive pulmonary disease
- on optimized medical therapy and in stable condition for at least 4 week
- desaturate in the 6 minute walking test by at least 4% to values <92%
Exclusion Criteria
- unstable conditions
- pregnant women
- patients with relevant concomitant lung disease and severe daytime hypoxemia
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Supplemental oxygen Oxygen application Supplemental oxygen will be applied via a mask during CPET Sham room air Oxygen application Room air will be applied similarly to oxygen
- Primary Outcome Measures
Name Time Method Watt 1 day Exercise time 1 day
- Secondary Outcome Measures
Name Time Method End-tidal pressures of carbon dioxide (PET CO2) 1 day Ventilatory equivalent of carbon dioxide (VE/VCO2) slope 1 day Peak Oxygen uptake 1 day Respiratory Exchange ratio 1 day Changes in arterial blood parameters 1 day
Trial Locations
- Locations (1)
University Hospital Zurich, Division of Pneumology
🇨ðŸ‡Zürich, Switzerland