Epigenetics Based Diagnosis of Diabetes in Saliva and Blood Samples
- Conditions
- Ectopic LipidsPrediabetic StateDiabetes Mellitus, Type 2Epigenetics Based Modifications
- Interventions
- Diagnostic Test: Blood samplingDiagnostic Test: Saliva and blood samplesDiagnostic Test: Magnet Resonance Spectroscopy
- Registration Number
- NCT04011228
- Lead Sponsor
- Medical University of Vienna
- Brief Summary
The aim of the present study is to investigate epigenetics based modifications and biomarkers in the saliva and blood in diabetic patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 224
- type 2 diabetic patients
- prediabetic patients
- women with gestational diabetes
- healthy control subjects without diabetes
- healthy pregnant women
- cancer disease
- infectious diseases such as hepatitis or HIV
- malignoms
- patients with claustrophoby
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Women with gestational diabetes Saliva and blood samples - Prediabetic patients Saliva and blood samples - Healthy control subjects Saliva and blood samples - Type 2 diabetic patients Saliva and blood samples - Type 2 diabetic patients Blood sampling - Healthy control subjects Blood sampling - Pregnant women without gestational diabetes Blood sampling - Prediabetic patients Blood sampling - Prediabetic patients Magnet Resonance Spectroscopy - Type 2 diabetic patients Magnet Resonance Spectroscopy - Women with gestational diabetes Blood sampling - Women with gestational diabetes Magnet Resonance Spectroscopy - Healthy control subjects Magnet Resonance Spectroscopy - Pregnant women without gestational diabetes Saliva and blood samples - Pregnant women without gestational diabetes Magnet Resonance Spectroscopy -
- Primary Outcome Measures
Name Time Method Specifying the microRNAs in saliva in diabetic patients 1 hour Characterization of microRNAs in saliva of prediabetic and type 2 diabetic patients, as well as in women with gestational diabetes and healthy control subjects.
- Secondary Outcome Measures
Name Time Method Correlation of the percentage of the content of fat in the skeletal muscle with miRNA´s in diabetic patients. 1 hour Correlation of miRNA´s in the saliva with the amount of ectopic lipids in the skeletal muscle.
Correlation of the percentage of liver fat with miRNA´s in diabetic patients. 1 hours Correlation of miRNA´s in the saliva with the amount of intrahepatic liver fat.
Correlation of the percentage of heart fat with miRNA´s in diabetic patients 1 hour Correlation of miRNA´s in the saliva with the amount of ectopic lipids in the heart.
Trial Locations
- Locations (1)
Medical University of Vienna
🇦🇹Vienna, Austria