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Epigenetics Based Diagnosis of Diabetes in Saliva and Blood Samples

Conditions
Ectopic Lipids
Prediabetic State
Diabetes Mellitus, Type 2
Epigenetics Based Modifications
Interventions
Diagnostic Test: Blood sampling
Diagnostic Test: Saliva and blood samples
Diagnostic Test: Magnet Resonance Spectroscopy
Registration Number
NCT04011228
Lead Sponsor
Medical University of Vienna
Brief Summary

The aim of the present study is to investigate epigenetics based modifications and biomarkers in the saliva and blood in diabetic patients.

Detailed Description

Not available

Recruitment & Eligibility

Status
UNKNOWN
Sex
All
Target Recruitment
224
Inclusion Criteria
  • type 2 diabetic patients
  • prediabetic patients
  • women with gestational diabetes
  • healthy control subjects without diabetes
  • healthy pregnant women
Read More
Exclusion Criteria
  • cancer disease
  • infectious diseases such as hepatitis or HIV
  • malignoms
  • patients with claustrophoby
Read More

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Arm && Interventions
GroupInterventionDescription
Women with gestational diabetesSaliva and blood samples-
Prediabetic patientsSaliva and blood samples-
Healthy control subjectsSaliva and blood samples-
Type 2 diabetic patientsSaliva and blood samples-
Type 2 diabetic patientsBlood sampling-
Healthy control subjectsBlood sampling-
Pregnant women without gestational diabetesBlood sampling-
Prediabetic patientsBlood sampling-
Prediabetic patientsMagnet Resonance Spectroscopy-
Type 2 diabetic patientsMagnet Resonance Spectroscopy-
Women with gestational diabetesBlood sampling-
Women with gestational diabetesMagnet Resonance Spectroscopy-
Healthy control subjectsMagnet Resonance Spectroscopy-
Pregnant women without gestational diabetesSaliva and blood samples-
Pregnant women without gestational diabetesMagnet Resonance Spectroscopy-
Primary Outcome Measures
NameTimeMethod
Specifying the microRNAs in saliva in diabetic patients1 hour

Characterization of microRNAs in saliva of prediabetic and type 2 diabetic patients, as well as in women with gestational diabetes and healthy control subjects.

Secondary Outcome Measures
NameTimeMethod
Correlation of the percentage of the content of fat in the skeletal muscle with miRNA´s in diabetic patients.1 hour

Correlation of miRNA´s in the saliva with the amount of ectopic lipids in the skeletal muscle.

Correlation of the percentage of liver fat with miRNA´s in diabetic patients.1 hours

Correlation of miRNA´s in the saliva with the amount of intrahepatic liver fat.

Correlation of the percentage of heart fat with miRNA´s in diabetic patients1 hour

Correlation of miRNA´s in the saliva with the amount of ectopic lipids in the heart.

Trial Locations

Locations (1)

Medical University of Vienna

🇦🇹

Vienna, Austria

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