Healthcare-associated Infections in Severe COVID-19 During 2020

Completed

• Conditions: Respiration, Artificial; Health Care Associated Infection; COVID-19
• Interventions: Other: COVID-19

• Registration Number: NCT04819165
• Lead Sponsor: Sanatorio Anchorena San Martin

Brief Summary

In patients who develop ARDS due to SARS-CoV-2 (CARDS), a longer duration of invasive mechanical ventilation (IMV) and ICU stay has been reported compared to ARDS not associated with SARS-CoV-2. Consequently, the days of stay in ICU increase Identifying the risk factors associated with the development of this complication and developing measures aimed at its prevention could have a favorable impact on the clinical course of seriously ill patients.

Detailed Description

The rate of catheter-associated bacteremia is 3.78 / 1000 days central venous catheters in polyvalent ICUs.

Some studies suggest that in the context of this pandemic, infections associated with health care have increased, although there are few data referring to Latin America.

The objective of this study is to analyze the incidence of health care associated infections in adult patients on invasive mechanical ventilation with confirmed COVID-19 diagnosis and negative COVID-19 admitted to the Intensive Care Unit of the Anchorena San Martín Clinic, San Martín, Buenos Aires.

Study Timeline

• Study Start: 2020-03-01
• Primary Completion: 2020-12-31
• Study Completion: 2021-01-31
• Status Verified: 2021-03
• Study First Submitted: 2021-03-25
• Study First Submitted QC: 2021-03-25
• Last Update Submitted: 2021-03-25
• Study First Posted: 2021-03-26
• Last Update Posted: 2021-03-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 252

Inclusion Criteria

• All patients older than 18 years admitted to the intensive care unit of the Anchorena San Martín Clinic who required invasive mechanical ventilation for more than 24 hours in a period between March 2020 and December 2020 were included in the analysis.

Exclusion Criteria

• All patients who presented incomplete data in the follow-up sheets were excluded.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
COVID-19 patients	COVID-19	Patients with invasive mechanical ventilation admitted to the Intensive Care Unit (UCI) of the Anchorena San Martín Clinic, San Martín, Buenos Aires with confirmed COVID-19 diagnosis (positive polymerase chain reaction in nasopharyngeal swab).

Primary Outcome Measures

Name	Time	Method
Incidence of health care associated infections in each group.	March to December 2020

Secondary Outcome Measures

Name	Time	Method
mortality in UCI	March to December 2020
Days of ICU stay	March to December 2020
Possible factors associated with Incidence of health care associated infections.	March to December 2020
Days of mechanical ventilation	March to December 2020
The most frequent pathogens in this population associated with Incidence of health care associated infections.	March to December 2020

Trial Locations

Locations (1)

Sanatorio Anchorena de San Martin; 🇦🇷 San Martín, Buenos Aires, Argentina