Post-COVID-19 Pneumo-hematocele

Completed

• Conditions: COVID-19 Respiratory Infection
• Interventions: Procedure: Pulmonary resection

• Registration Number: NCT05067881
• Lead Sponsor: Hospital General Ajusco Medio

Brief Summary

Introduction. As the COVID-19 pandemic has continued, an increasing number of long-term complications are emerging. Recently, the appearance of characteristic pulmonary lesions has been noted, being described as post COVID-19 pneumatocele. The aim of this study is to describe the clinical, histopathologic and imaging features of post COVID-19 pneumo-hematoceles (PHC) and secondarily to suggest a treatment algorithm in these patients.

Methods. A retrospective study was performed in patients admitted with diagnosis of SARS-CoV2 infection from March 2020 to September 2021 who presented PHC on imaging studies. Clinical and demographic variables were recorded and CT scans were analyzed. A logistic regression analysis was performed to determine the risk for rupture according to PHC characteristics.

It appears that PHC occurs secondary to encapsulation of blood accumulation, the result of micro capillary bleeding, with partial reabsorption of blood and subsequent air filling. The recommendation is to operate on patients with PHC of 5cm and those with persistent lesions of 3cm.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-03-01
• Primary Completion: 2020-03-01
• Study Completion: 2021-09-20
• Study First Submitted: 2021-09-28
• Status Verified: 2021-10
• Study First Submitted QC: 2021-10-01
• Last Update Submitted: 2021-10-01
• Study First Posted: 2021-10-05
• Last Update Posted: 2021-10-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 37

Inclusion Criteria

• Adults with a positive protein chain reaction for SARS-CoV2,
• PHC on imaging studies.

Exclusion Criteria

• loss of follow up
• age out of range.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Pneumohematocele	Pulmonary resection	Patients with SARS CoV-2 diagnosis and PHC on imaging studies

Primary Outcome Measures

Name	Time	Method
PHC diagnosis	From date of diagnosis until 4 weeks after diagnosis	Pneumohematoceles on imaging studies

Trial Locations

Locations (1)

Karla Verónica Chávez Tostado; 🇲🇽 Mexico City, Mexico