Assessment of the 90-day Mortality Risk Score After Video-assisted Thoracoscopic Lobectomy in the Italian VATS Group Cohort
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 2,209
- Primary Endpoint
- 90-day postoperative mortality
Study Overview
Brief Summary
A five classes (A-E) aggregate risk score predicting 90-day mortality after video-assisted thoracoscopic lobectomy for lung cancer, including as independent factors male sex (3 points), carbon monoxide lung diffusion capacity <60% (1 point) and operative time >150 minutes (1 point), has been recently published. This study aims to assess the effectiveness and reliability of this risk model in a large, independent cohort of patients, in order to confirm its generalizability.
Detailed Description
From the Italian VATS Group Database, we selected patients who underwent video-assisted thoracoscopic lobectomy for non-small cell lung cancer. We calculated the aggregate risk score and the corresponding class of 90-day mortality risk for each patient. The correlation between risk classes and mortality rates was tested by Spearman's rho-test. Model calibration was evaluated by Hosmer-Lemeshow goodness-of-fit test.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients undergoing VATS lobectomy for non-small cell lung cancer
Exclusion Criteria
- •Incomplete data for risk score calculation
- •Tumor size >5 cm
- •Follow-up <3 months
- •Patients undergoing neoadjuvant treatment
- •Patients undergoing extended resection
Outcomes
Primary Outcomes
90-day postoperative mortality
Time Frame: 90 day post surgical procedure
Alive/Death (cause of death)
Secondary Outcomes
No secondary outcomes reported
Investigators
Maria Cattoni
Principal Investigator - Clinician at Center for Thoracic Surgery - School of Medicine and Surgery - University of Insubria - Varese
Università degli Studi dell'Insubria