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临床试验/NCT01726725
NCT01726725Unknown不适用

Investigating the Etiology of Hemifacial Spasm (HFS): The Role of Desflurane

University of Manitoba0 个研究点目标入组 25 人开始时间: 2012年11月最近更新:
适应症
干预措施
相关药物

试验速览

阶段
不适用
入组人数
25
主要终点
Measure EMG responses to peripheral nerve stimulation and motor cortex stimulation during changes in desflurane levels

研究概览

简要总结

Patients are chosen to participate in this study because they will undergo a particular type of brain surgery to treat their hemifacial spasm. This surgery is called microvascular decompression (MVD) and involves the facial nerve. The facial nerve is being compressed by one or more blood vessels and this contact produces the facial twitches. The investigators do not know why a blood vessel that touches the facial nerve produces facial twitches. The investigators are interested in investigating this during your surgery. A total of 25 participants are expected to participate in this study.

详细描述

"Intra Operative Monitoring" (IOM) is a standard and routine medical practice for patients having MVD surgery. IOM is done to make sure that the hearing and face nerves are not accidentally bumped or damaged during surgery. After anesthetic induction, the neurophysiologist places electrodes for the nerves, on the scalp and muscles. Stimulation and monitoring of muscle twitches are all common, safe and painless medical procedures.

In this study, the investigators would like to measure the nerve and muscle function on the normal side and compare it to nerve and muscle function on the abnormal side during different levels of the anesthetic desflurane. In order to monitor the normal side of the face one additional set of electrodes will be placed in the facial muscles. The investigators will compare responses to three different levels of anesthetic. The technique used will be motor evoked potentials. The effect of the anesthesia on the lateral spread response will also be examined. This response is evident only on the symptomatic side. These observations will take approximately 10 to 15 minutes and will not delay or lengthen the surgery.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Prospective

入排标准

年龄范围
18 Years 至 75 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • patients referred to the neurosurgical service for microvascular decompression surgery for HFS
  • males and females 18 to 75 years of age
  • otherwise normal neurological exam
  • signed informed consent

排除标准

  • Botox treatment within the last three months

研究组 & 干预措施

hemifacial spasm, lateral spread, motor evoked potentials

EMG recordings from facial muscles of HFS patients during MVD surgery will be compared during total intravenous anesthesia (propofol), 0.5 MAC desflurane and 1.0 MAC desflurane

干预措施: desflurane (Drug)

结局指标

主要结局

Measure EMG responses to peripheral nerve stimulation and motor cortex stimulation during changes in desflurane levels

时间窗: one year

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

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