Mechanisms of the development of chronic lung disease in very preterm infants - a prospective observational cohort study

• Conditions: P22.0; Respiratory distress syndrome of newborn

• Registration Number: DRKS00034843
• Lead Sponsor: niversitätsklinikum Ulm, Klinik für Kinder-und Jugendmedizin, Sektion Neonatologie und pädiatrische Intensivmedizin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-08-12
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 600

Inclusion Criteria

Gestational Age: All very preterm infants (VLBW infants) born at = 32+0 weeks of gestation at the Perinatal Center Ulm.
- Healthy Term-Born Newborns: Newborns who are healthy and born at term.
- Pregnant Women with Intact Pregnancies: Pregnant women undergoing amniocentesis or fetal interventions.

Exclusion Criteria

- Severe congenital malformations: According to international classification systems, excluding inguinal hernias, PDA, atrial septal defects, ventricular septal defects, and all congenital anomalies that do not affect pulmonary, cardiovascular, and psychomotor capacities.
- Severe genetic disorders: Excluding genetic disorders that are not relevant to pulmonary, cardiovascular, and psychomotor outcomes.
- Severe metabolic diseases: Excluding hyperglycemia of the preterm infant.
- Birth before 22+0 weeks of gestation.
- Palliative care decision: Before inclusion in the study.
- No parental consent.
- Withdrawal of consent.

Study & Design

• Study Type: observational
• Study Design: Not specified