Obesity, Pain and Fertility: is There Any Association?
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Progressive motility
研究概览
简要总结
The overall aim of the study is to investigate if patients with musculoskeletal chronic pain have reduced semen quality in comparison with age matched healthy controls. Secondly, the aim is to investigate whether overweight with or without chronic pain are related to reduced semen quality. We will investigate semen quality in obese chronic pain patients, normal weight chronic pain patients and in obese and normal weight healthy controls.
详细描述
Obesity is associated with several disorders including chronic musculoskeletal pain. For example obesity has been implicated in the development or progression of low back pain and knee osteoarthritis. The mechanism by which obesity causes lumbar back pain is poorly understood, but the contribution of both mechanical and system factors is likely. Direct mechanical stress on the intervertebral discs and adjacent structures are suspected to be mechanisms through which obesity affects the spine, leading to subsequent low back pain. The link between obesity and knee osteoarthritis has also been demonstrated, but potential factors underlying the association of obesity with knee osteoarthritis has not entirely been elucidated.
It is a well-known fact that obesity leads to an excess load on the joint, increased cartilage turnover, increased collagen type 2 degradation products and increased risk of degenerative meniscal lesions. Although all of these factors have been proposed to lead to knee osteoarthritis, no causal relationship has been demonstrated.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Men between 18-45 years with low back pain or knee pain recruited among referees to the orthopaedic outpatient clinics at Aalborg University Hospital
- •Pain more than 3 months
- •Patients can be on a daily use of Paracetamol 1 gram x 4, NSAID x 3-4 or combined
- •Patients will be included regardless of their BMI but will be put in their respective BMI subgroup after the required measurements have been taken
- •Regarding low back pain the LBPRS >9, knee pain the KOOS <75 (0-100, i.c. 100 = no problems)
- •Healthy men in the age 18-45 years (matched with enrolled patients)
排除标准
- •Malignancy
- •Ongoing infection
- •Drug addiction defined as the use of cannabis, opioids or other psycho drugs
- •Previous neurologic, musculoskeletal or mental diseases
- •Lack of ability to cooperate
- •Pain rating
- •Patients with a pain rate below 3
- •Medication
- •Patients taking Morphine drugs
结局指标
主要结局
Progressive motility
时间窗: 6 months
Progressive motility as in the world health organization lower reference limits for sperm quality.
次要结局
- Pain(6 months)