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临床试验/NCT06629350
NCT06629350已完成不适用

ASA Prediction Using Health Data and Medication Use

Erasmus Medical Center1 个研究点 分布在 1 个国家目标入组 149,422 人开始时间: 2024年6月25日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
149,422
试验地点
1
主要终点
The American Society of Anesthesiologists physical status (ASA-PS) class

研究概览

简要总结

The development of a machine learning algorithm that predicts American Society of Anesthesiologist-Physical Status (ASA-PS) based on preoperative variables would not only improve clinical decision-making in patient risk stratification but also offer a more reliable tool for administrative and regulatory uses. Therefore, the development of such a machine learning tool presents a significant opportunity to advance both the science and practice of perioperative care. Incorporating medication use into the algorithm could further enhance its predictive power, as it is closely linked to systemic disease. This addition could help refine the ASA-PS classification, making it an even more valuable tool in the clinical setting.

详细描述

The American Society of Anesthesiologists Physical Status (ASA-PS) classification system is a widely used tool for assessing surgical fitness and other clinical contexts. However, its inherent subjectivity and heavy reliance on clinician judgment can lead to inconsistencies in patient risk stratification, a critical component of perioperative care. Furthermore, the ASA-PS system has been adopted for various administrative and regulatory purposes beyond its original intent, such as quality assessment by the Dutch Health and Youth Care Inspectorate (IGJ), compensation decisions by private payers in the USA, patient triage, and determining suitability for certain types of surgery.

Given the broad and critical applications of the ASA-PS system, enhancing its precision and objectivity is of paramount importance. One way to achieve this is through the development of a machine learning algorithm that predicts ASA-PS based on preoperative variables. Anesthesiologists base the ASA-PS score on the presence of systemic diseases, which can be inferred from medication use. By leveraging data such as Anatomical Therapeutic Chemical (ATC) codes, BMI, sex, age, routinely collected preoperative health data, and medication use, this algorithm could provide a more consistent and objective measure of ASA-PS.

This would not only improve clinical decision-making in patient risk stratification but also offer a more reliable tool for administrative and regulatory uses. Therefore, the development of such a machine learning tool presents a significant opportunity to advance both the science and practice of perioperative care. Incorporating medication use into the algorithm could further enhance its predictive power, as it is closely linked to systemic disease. This addition could help refine the ASA-PS classification, making it an even more valuable tool in the clinical setting.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Underwent a surgical, diagnostic or therapeutic procedure within the surgical suite of the Erasmus MC, and
  • ASA-PS score recorded in electronic medical record (EMR), and
  • A verified medication list in EMR, or a filled out preoperative anesthesiological health questionnaire registered in EMR

排除标准

  • Age <18 at moment of surgery, or
  • ASA-PS V-VI, or
  • Opt-out registered in EMR

结局指标

主要结局

The American Society of Anesthesiologists physical status (ASA-PS) class

时间窗: Day 0

The dependent response variable will be the ASA-PS class, both as a four-level variable (ASA-PS I, II, III and IV) and a two-level variable (ASA-PS I and II versus ASA-PS III and IV). The ASA-PS class was assigned to the patient and recorded in the patients file in the EMR by an anesthesiologist of resident anesthesiology as a part of the routinely performed preoperative anesthesiological screening in preparation for a procedure.

次要结局

  • Performance metrics: accuracy(day 0)
  • Performance metrics: precision(day 0)
  • Performance metrics:recall(day 0)
  • Performance metrics: F1-score(day 0)
  • Performance metrics: Area Under the Receiver Operating Characteristic Curve(day 0)
  • Calibration(Day 0)
  • Misclassification of the ASA-PS score(Day 0)
  • Explainability of the prediction model:Shapley additive explanations (SHAP)(day 0)
  • Explainability of the prediction model:Local interpretable model-agnostic explanations (LIME)(day 0)
  • Optimal sample size(day 0)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Jan-Wiebe Korstanje

principal investigator

Erasmus Medical Center

研究点 (1)

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