ISRCTN98405441
已完成
3 期
A comparison of 5-FU and leucovorin treatment as bolus injection or continuous infusion in the adjuvant therapy of Dukes' B, C and radically operated D colorectal cancer: a randomized phase III trial studying toxicity, cost-benefit and quality of life in bolus injection and continuous infusion treatment regimens, effects of nutrition and nutritional support, changes in bacterial flora and prognostic factors
Helsinki University Central Hospital (Finland)0 个研究点目标入组 450 人2012年7月16日
概览
- 阶段
- 3 期
- 干预措施
- 未指定
- 疾病 / 适应症
- Radically operated colorectal cancer Stage II-IV
- 发起方
- Helsinki University Central Hospital (Finland)
- 入组人数
- 450
- 状态
- 已完成
- 最后更新
- 4年前
概览
简要总结
2007 Results article in http://www.ncbi.nlm.nih.gov/pubmed/17895895 results 2020 Other publications in https://pubmed.ncbi.nlm.nih.gov/32790589/ post-hoc analysis (added 17/08/2020) 2021 Other publications in https://pubmed.ncbi.nlm.nih.gov/34359796/ Lead Time and Prognostic Role of Serum CEA, CA19-9, IL-6, CRP, and YKL-40 after Adjuvant Chemotherapy in Colorectal Cancer (added 09/08/2021)
研究者
入排标准
入选标准
- •1\. Aged 18 to 75 years
- •2\. Had histologically confirmed radically operated stage II\-IV colorectal cancer (CRC)
- •3\. WHO performance status 0 ? 2 and adequate bone marrow, kidney and liver function
排除标准
- •1\. Presence of other invasive cancer than CRC in history except for adequately treated carcinoma in situ of the cervix or non\-melanoma skin cancer
- •2\. Metabolic, neurological or psychiatric illness that was incompatible with chemotherapy
- •3\. Serious thromboembolic event currently under treatment
- •4\. Pregnancy, lactation or absence of adequate contraception in fertile patients
结局指标
主要结局
未指定
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