Efficacy of Nebulized Versus Intravenous N- Acetylcysteine in Airway Clearance in Broncheictasis
Overview
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Assiut University
- Enrollment
- 70
- Primary Endpoint
- sputum viscosity score
Overview
Brief Summary
It has been deduced that reducing the production of mucus or improving the clearance of sputum in the airway is the key to enhance the therapeutic efficacy for bronchiectasis . Mucoactive drugs are commonly used to clear the airway in mucus hypersecretion diseases. Currently, investigators have found that N-acetylcysteine (NAC), an effective mucolytic agent, not only reduces the viscosity and elasticity of sputum, but it also has anti-inflammatory and antioxidant activity.
Additionally, the Spanish guidelines on the treatment of bronchiectasis indicate that the use of N-acetylcysteine should be considered for patients with bronchiectasis and COPD. Therefore, as a classic mucolytic agent with antioxidant and anti-inflammatory properties, N-acetylcysteine can be effective in the treatment of bronchiectasis
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Triple (Participant, Care Provider, Investigator)
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Subjects aged above 18 years old; with a diagnosis of bronchiectasis who are admitted to chest department due to acute exacerbation
Exclusion Criteria
- •current smokers, a known allergy to N-acetylcysteine; pregnancy or lactation (for women); primary diagnosis of COPD or asthma
Arms & Interventions
IV N Acetyle cysteine
Intervention: N Acetyle cysteine given by IV injection
Intervention: N Acetyle cysteine given by IV injection (Drug)
Nebulized N Acetyle cysteine
Intervention: Nebulized N Acetyle cysteine
Intervention: Nebulized N Acetyle cysteine (Drug)
Outcomes
Primary Outcomes
sputum viscosity score
Time Frame: At the end of 1 week of treatment
Sputum viscosity score \\(0\\): Normal (liquid)\\(1\\): Mildly increased viscosity (fluid)\\(2\\): Moderately increased viscosity (viscous)\\(3\\): Severely increased viscosity (sticky)
Amount of sputum
Time Frame: At the end of 1 week treatment
Expectoration difficulty score
Time Frame: At the end of 1 week of treatment
Expectoration difficulty score \\(0\\): No difficulty\\(1\\): Mild difficulty\\(2\\): Moderate difficulty\\(3\\): Marked difficulty
Secondary Outcomes
- Need for mechanical ventilation(At the end of 1 week of treatment)
Investigators
Sahar Refaat Mahmoud
Dr
Assiut University