NCT00779844终止4 期
Intravenous Anesthesia in Obese Patients: Propofol and Remifentanil Requirements
适应症
试验速览
- 阶段
- 4 期
- 状态
- 终止
- 发起方
- Hopital Foch
- 入组人数
- 63
- 试验地点
- 2
- 主要终点
- Dose of propofol administered
研究概览
简要总结
Pharmacokinetic models for anesthetic agents are questionable. The objective of the study is to compare the propofol and remifentanil doses required to maintain the bispectral index in the range 40-60 in two groups of patients: obese patients and lean patients
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients scheduled for a bariatric coelioscopic surgical procedure (obese patients) or for an upper abdominal laparoscopic procedure (lean patients)
排除标准
- •age lower than 18 years,
- •pregnant woman,
- •presence of a central neurological disorder or a lesion cerebral, of a severe respiratory or hepatic insufficiency,
- •allergy to propofol, or to soja or to peanuts, or to sufentanil, or to remifentanil, or to morphine, or to a muscle myorelaxant, or to an excipient,
- •hypersensibility to sufentanil, or to remifentanil or to another derivate of fentanyl,
- •allergy to latex,
- •presence of a symptomatic gastroesophageal reflux,
- •patients receiving a psychotropic treatment or a agonist-antagonist opiate,
- •presence of predictive signs of difficult mask ventilation of difficult intubation (else than obesity)
结局指标
主要结局
Dose of propofol administered
时间窗: intraoperatively
次要结局
- remifentanil requirement, hemodynamic profile, time to extubation, performances of the automated system of propofol and remifentanil deliver(intraoperatively)
研究者
研究点 (2)
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