Evaluation of Wound Dressings to Reduce the Harmful Effects of Shear- Force at the Skin
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pressure Ulcer
- Sponsor
- Maastricht University Medical Center
- Enrollment
- 10
- Primary Endpoint
- Cutaneous blood flow, erythema index, IL-1alpha/Total protein ratio
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The purpose of this study is to investigate if wound dressings are capable in reducing the effects of shear- force at the skin. With our own shear- force model we are able to apply 19 Newton shear- force combined with 9 newton pressure at the skin of the non- dominant forearm. After half an hour we measure IL-1alpha/ total protein- ratio, cutaneous blood flow (Laser doppler, Moor LDI) and the erythema index (DSMIIColormeter) which occurs as an effect of shear- force application at the skin.
Then, we apply 19 Newton shear- force combined with 9 Newton pressure at the dominant fore-arm but this time we put a wound dressing between the skin and shear- force model. After half an hour we measure the IL-1alpha/total protein-ratio, cutaneous blood flow and the erythema index.
This research consists of three research day, each day we are going to investigate a different wound dressing
Investigators
Eligibility Criteria
Inclusion Criteria
- •healhty volunteer
- •age 18- 30
- •BMI 20- 30
Exclusion Criteria
- •Trauma fore-arms
- •Diabetes mellitus type I or type II
- •The use of NSAID's in the last 7 days
- •Vascular diseases
- •Muscular dystrophy
- •Malignancy
- •Participant is unable to give informed consent
Outcomes
Primary Outcomes
Cutaneous blood flow, erythema index, IL-1alpha/Total protein ratio
Time Frame: Directly after intevention