Evaluation of Wound Dressings to Reduce the Harmful Effects of Shear- Force at the Skin
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 主要终点
- Cutaneous blood flow, erythema index, IL-1alpha/Total protein ratio
研究概览
简要总结
The purpose of this study is to investigate if wound dressings are capable in reducing the effects of shear- force at the skin. With our own shear- force model we are able to apply 19 Newton shear- force combined with 9 newton pressure at the skin of the non- dominant forearm. After half an hour we measure IL-1alpha/ total protein- ratio, cutaneous blood flow (Laser doppler, Moor LDI) and the erythema index (DSMIIColormeter) which occurs as an effect of shear- force application at the skin.
Then, we apply 19 Newton shear- force combined with 9 Newton pressure at the dominant fore-arm but this time we put a wound dressing between the skin and shear- force model. After half an hour we measure the IL-1alpha/total protein-ratio, cutaneous blood flow and the erythema index.
This research consists of three research day, each day we are going to investigate a different wound dressing
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healhty volunteer
- •age 18- 30
- •BMI 20- 30
排除标准
- •Trauma fore-arms
- •Diabetes mellitus type I or type II
- •The use of NSAID's in the last 7 days
- •Vascular diseases
- •Muscular dystrophy
- •Malignancy
- •Participant is unable to give informed consent
结局指标
主要结局
Cutaneous blood flow, erythema index, IL-1alpha/Total protein ratio
时间窗: Directly after intevention
次要结局
未报告次要终点