Prone Duration in COVID-19 ARDS

Completed

• Conditions: COVID - 19; Acute Respiratory Distress Syndrome (ARDS)

• Registration Number: NCT06765759
• Lead Sponsor: Istanbul University - Cerrahpasa

Brief Summary

The aim of this observational study is to learn the effects of prone position duration on patient outcomes in patients with severe acute respiratory distress syndrome (ARDS) due to Coronavirus Disease - 2019 (COVID-19). The main question it aims to answer is:

Does the length of prone position duration affect gas exchange in patients with severe ARDS and is there a difference between genders in this regard? The differences in gas exchange between those who have been in prone position for 16-24 hours and those who have been in prone position for 24-36 hours as part of severe ARDS treatment will be examined.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-01-01
• Primary Completion: 2024-03-30
• Study Completion: 2024-06-30
• Status Verified: 2025-01
• Study First Submitted: 2025-01-03
• Study First Submitted QC: 2025-01-07
• Last Update Submitted: 2025-01-07
• Study First Posted: 2025-01-09
• Last Update Posted: 2025-01-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 79

Inclusion Criteria

• >18 years old
• hospitalized for more than 48 hours
• patients diagnosed with COVID-19
• intubated patients
• underwent prone positioning for longer than 16 hours starting from the first session

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Exclusion Criteria

• Pregnant females
• Patients under the age of 18
• Those who did not reach 16 hours duration of prone position for various reasons (unintentional extubation, ventilation problems, hemodynamic instability, cardiac arrest-prearrest)

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Calculation of PaO2/FiO2 ratio during short and long prone periods	At each prone session, calculation will be started one hour before the pronation and finished one hour after returning supine.	Partial arterial oxygen pressure/Fraction of inspired oxygen (PaO2/FiO2) ratio changes before, during and after pronation at each group will be calculated.

Secondary Outcome Measures

Name	Time	Method
Measurement of PaCO2 during short and long prone periods	At each prone session, measurement will be started one hour before the pronation and finished one hour after returning supine.	Partial arterial carbon dioxide pressure (PaCO2) changes before, during and after pronation at each group will be measured.
Measurement of PEEP during short and long prone periods	At each prone session, measurement will be started one hour before the pronation and finished one hour after returning supine.	Positive end-expiratory pressure (PEEP) changes before, during and after pronation at each group will be measured.

Trial Locations

Locations (1)

İstanbul University - Cerrahpaşa, Cerrahpaşa Medical Faculty; 🇹🇷 Istanbul, Turkey