Identification of Noninvasive Biomarkers for Neonates Undergoing Abdominal Surgery
Recruiting
- Conditions
- NeonateBiomarkers
- Interventions
- Other: Biomarkers
- Registration Number
- NCT05181423
- Lead Sponsor
- West China Hospital
- Brief Summary
To identify the potential serum and radiological biomarkers with regard to neonates undergoing abdominal surgery, and to further evaluate the prognostic value of these markers.
- Detailed Description
First, the investigators will collect serum biomarkers in neonate patients receiving abdominal surgery. Then the investigators will identify the characteristics and change of biomarkers expressed in neonate patients before and after abdominal surgery. The investigators will further evaluate the prognostic value of these markers for neonate patients receiving abdominal surgery.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 2000
Inclusion Criteria
- Age up to 18 years old
- With written informed consent
Exclusion Criteria
- Clinical data missing
- Without written informed consent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Retrospective cohort Biomarkers The internal cohort was retrospectively enrolled in West China Hospital, Sichuan University from June 2010 and December 2020. It is a training and internal validation cohort. Prospective cohort Biomarkers The same inclusion/exclusion criteria were applied for the same center prospectively. It is a external validation cohort.
- Primary Outcome Measures
Name Time Method Value of non-invasive biomarkers At least 5-year follow up These markers will be collected in association with the prognostication for neonates before and after surgery.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
West China Hospital, Sichuan University
🇨🇳Chengdu, Sichuan, China