Acoustic analysis of cough in head and neck cancer patients with swallowing disorders

Not Applicable

Completed

• Conditions: Dysphagia and aspiration risk; Signs and Symptoms

• Registration Number: ISRCTN16540497
• Lead Sponsor: Institut Jules Bordet

Brief Summary

2023 Protocol article in https://pubmed.ncbi.nlm.nih.gov/37773172/ (added 02/10/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-06-23
• Study Completion: 2023-09-30
• Last Update Posted: 16 October 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 71

Inclusion Criteria

1. Healthy volunteers
2. Head and neck cancer patients

Exclusion Criteria

Exclusion criteria for healthy volunteers:
1. Respiratory diseases
2. Dysphonia

Exclusion criteria for patients:
1. Respiratory disease

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Identification of a valid set of reference acoustic features in healthy subjects measured using temporal and spectral analyses at baseline. The temporal analysis includes signal duration, amplitude, sample entropy (turbulence noise) and kurtosis (burst). Acoustic cough-related features are recorded using skin contact and acoustic microphones, and analyzed with software developed for the project. The spectral analysis includes relative signal energies in the bands (0 Hz – 400 Hz), (400 Hz – 800 Hz), (800 Hz – 1600 Hz), (1600 Hz – 3200 Hz), the interval between 3200Hz and half the sampling frequency (22050 kHz) as well as the weighted frequency.