Metabolic Risk Factors and Myocardial Oxygenation Reserve (META-MORE)
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- Global and segmental Myocardial oxygenation reserve (MORE)
研究概览
简要总结
The purpose of this study is to use MRI images using the OS-CMR technique to view the differences in the hearts of healthy volunteers and participants with a condition called Metabolic Syndrome. The objectives of this project are to compare these two groups and to view how health risks, blood test results, and the time since a Metabolic diagnosis can affect heart health.
详细描述
Myocardial oxygenation changes during vasoactive breathing maneuvers, observed with oxygenation-sensitive cardiac MRI, will be identified and compared between individuals considered healthy and those fitting the criteria of the Metabolic Syndrome.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patient Participants:
- •Age 18-80
- •Informed Consent
- •Diagnosis of MetS (through at least 3 MetS characteristics (abdominal obesity, high triglyceride level, low HDL cholesterol, high systolic blood pressure, and high fasting glucose levels)
- •Healthy Volunteers:
- •Age 18-80
- •No known current or pre-existing significant medical problems that would affect the cardiovascular or respiratory system
- •No Smoking
排除标准
- •General MRI contraindications*
- •Pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, knowledge or suspicion of pregnancy.
- •Consumption of caffeine (coffee, tea, cocoa, chocolate, "energy drink") during the 12 hours prior to the exam
结局指标
主要结局
Global and segmental Myocardial oxygenation reserve (MORE)
时间窗: Baseline
A t-test will be used to assess the difference in global and segmental MORE, at rest, during hyperventilation, and throughout breath hold, between healthy and volunteers and MetS patients.
Relation between Breathing maneuver induced MORE and known MetS risk factors.
时间窗: Baseline
A linear regression will assess the relation between Breathing maneuver induced MORE and known MetS risk factors, biomarkers, and time since diagnosis.
次要结局
未报告次要终点
研究者
Matthias Friedrich
Principal Investigator
McGill University Health Centre/Research Institute of the McGill University Health Centre