Effects of Intravenous Lidocaine on Serum miRNA-135a and Its Downstream Proteins Rock2 and Add1 in Elderly Patients Undergoing Non-cardiac Surgery Under General Anesthesia.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 主要终点
- Changes from Baseline Add1 at the end of surgery immediately and 1, 3days after surgery
研究概览
简要总结
The purpose of this study is to investigate the effects of intravenous lidocaine on serum miRNA-135a and its downstream proteins Rock2 and Add1 in elderly patients undergoing non-cardiac under general anesthesia.
详细描述
Postoperative cognitive dysfunction (POCD) is a major complication following surgeries and anesthesia, especially in elderly individuals. Lidocaine, an inexpensive, widely available, and relatively safe compound, is a local anesthetic that readily crosses the blood-brain barrier. Intravenous lidocaine can reduce the incidence of POCD. However, the mechanism is still unclear.
Rock2 and Add1, which are regulated by miRNA-135a, play a key role in learning, memory, and cognition.
The objective of this study is to investigate the efficacy of intravenous lidocaine on the incidence of early POCD, and the levels of Rock2, Add1, and miRNA-135a in elderly patients undergoing non-cardiac under general anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 65 Years 至 80 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing elective non-cardiac surgery under general anesthesia
- •ASA physical status II-III
- •Aged ≥65 years
排除标准
- •Serious heart, lung, liver and kidney diseases
- •Central nervous system injury
- •Mental illness and drug dependence
- •On regular use of analgesic/sedative/antidepressant
- •Unable to cooperate
- •Allergy to lidocaine
- •MMSE < 23 points
研究组 & 干预措施
Lidocaine
Intravenous bolus of 1.5 mg/kg of lidocaine followed by a continuous infusion of 3.0 mg/kg for the first hour, 1.5 mg/kg for the second hour, 0.7 mg/kg until the end of the surgery.
干预措施: Lidocaine (Drug)
Normal saline
Normal saline administered as a bolus and an infusion with identical volume and rate changes as the treatment group.
干预措施: Normal saline (Drug)
结局指标
主要结局
Changes from Baseline Add1 at the end of surgery immediately and 1, 3days after surgery
时间窗: at preoperation, at the end of surgery immediately, 1day and 3day after surgery
Venous blood was extracted, and the serum Add1 level of patients were detected by PCR and ELISA before surgery, at the end of surgery, 1day and 3day after surgery
Changes from Baseline Rock2 at the end of surgery immediately and 1, 3days after surgery
时间窗: at preoperation, at the end of surgery immediately, 1day and 3day after surgery
Venous blood was extracted, and the serum Rock2 level of patients were detected by PCR and ELISA before surgery, at the end of surgery, 1day and 3day after surgery
Changes from Baseline miRNA-135A at the end of surgery immediately and 1, 3days after surgery
时间窗: at preoperation, at the end of surgery immediately, 1day and 3day after surgery
Venous blood was extracted, and the serum miRNA-135a level of patients were detected by PCR and ELISA before surgery, at the end of surgery, 1day and 3day after surgery
次要结局
- Changes from Baseline mini-mental state examination (MMSE) at the end of surgery immediately and 1, 3days after surgery(at preoperation,1day and 3day after surgery)