NCT03873935已完成不适用
Evaluation of Vitamin D on Periodontal and Cardiovascular Diseases Progression
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 179
- 试验地点
- 1
- 主要终点
- Clinical Attachment level
研究概览
简要总结
Vitamin D has been considered to possess anti-inflammatory and antimicrobial activity which may be a link for the known interaction of periodontitis (CP) and coronary heart disease (CHD). This study investigated the association between serum vitamin D levels and periodontitis in patients with CP and with CHD. Furthermore, the objective was to determine if periodontitis and CHD had an impact on serum vitamin D levels.
详细描述
Using a cross-sectional design, a total of 39 patients with CP, 38 patients with CHD, 38 patients with both CP and CHD, and 37 healthy subjects will enrolled in the present study.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 25 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Presence of at least twenty teeth
- •CP with a minimum of 40% of sites with a clinical attachment level (CAL) ≥2mm and probing depth (PD) ≥4mm;
- •Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs
- •Presence of ≥40% sites with bleeding on probing (BOP)
排除标准
- •Intake of contraceptives
- •Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study
- •Status of pregnancy or lactation
- •Previous history of excessive drinking
- •Allergy to local anaesthetic
- •Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.
结局指标
主要结局
Clinical Attachment level
时间窗: 1 year
Clinical Analysis
次要结局
未报告次要终点
研究者
Gaetano Isola, DDS, PhD
Principal Investigator
University of Messina
研究点 (1)
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