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临床试验/NCT06176872
NCT06176872尚未招募不适用

Assessment of Cardiac CT Angiography in Patients Undergoing Thrombectomy for Ischemic Stroke

Universitätsklinikum Hamburg-Eppendorf0 个研究点目标入组 165 人开始时间: 2024年1月1日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
165
主要终点
Diagnosis of therapy-relevant CAD and concomitant cardiac findings resulting in new therapeutic measurements.

研究概览

简要总结

Mortality rates after acute ischemic stroke remain high despite continuously improving treatment. In this context, it is important to note that a relevant portion of acute ischemic stroke patients die from adverse cardiovascular events, such as myocardial infarction, rather than from complications associated with the stroke itself. A possible reason might be that this patient group often suffers from at least moderate asymptomatic coronary artery disease. This study seeks to integrate cardiac computed tomography angiography into the standard-of-care diagnostic protocol of acute ischemic stroke. The aim of this prospective mono-centric trial is to enable accurate diagnosis of therapy-relevant coronary artery disease, other concomitant cardiac findings and cardiac causes of acute ischemic stroke, without delaying stroke therapy. In the long-run, the goal is to investigate whether cardiac computed tomography angiography and the resulting therapeutic measures (interventions or medications added) can improve functional outcome and rate of adverse cardiac complications in patients with acute ischemic stroke compared to a retrospective matched-cohort of patients without cardiac CT imaging.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
40 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients aged 40 years or above, presenting at the Emergency Department of the University Medical Center Hamburg-Eppendorf with a suspected acute ischemic stroke and a relevant neurological deficit (NIHSS score > 4).

排除标准

  • A causal differential diagnosis for the acute stroke syndrome with absent intracranial vessel occlusion.
  • No correlation for the patients' symptoms in the cranial CTA (no vessel obstruction).

结局指标

主要结局

Diagnosis of therapy-relevant CAD and concomitant cardiac findings resulting in new therapeutic measurements.

时间窗: 1 day at hospital discharge

Number of (newly) prescribed medications (e.g., anticoagulants), cardiac diagnostics/interventions/planned interventions, clinical status (NIHSS, mRs).

次要结局

  • The rate of adverse cardiovascular events (MACE).(90 and 365 days)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Gabriel Broocks

Senior physician

Universitätsklinikum Hamburg-Eppendorf

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