Cardiac CT Angiography in Patients With Acute Ischemic Stroke

Not yet recruiting

• Conditions: Acute Ischemic Stroke; Coronary Artery Disease
• Interventions: Diagnostic Test: Cardiac Computed Tomography Angiography

• Registration Number: NCT06176872
• Lead Sponsor: Universitätsklinikum Hamburg-Eppendorf

Brief Summary

Mortality rates after acute ischemic stroke remain high despite continuously improving treatment. In this context, it is important to note that a relevant portion of acute ischemic stroke patients die from adverse cardiovascular events, such as myocardial infarction, rather than from complications associated with the stroke itself. A possible reason might be that this patient group often suffers from at least moderate asymptomatic coronary artery disease. This study seeks to integrate cardiac computed tomography angiography into the standard-of-care diagnostic protocol of acute ischemic stroke. The aim of this prospective mono-centric trial is to enable accurate diagnosis of therapy-relevant coronary artery disease, other concomitant cardiac findings and cardiac causes of acute ischemic stroke, without delaying stroke therapy. In the long-run, the goal is to investigate whether cardiac computed tomography angiography and the resulting therapeutic measures (interventions or medications added) can improve functional outcome and rate of adverse cardiac complications in patients with acute ischemic stroke compared to a retrospective matched-cohort of patients without cardiac CT imaging.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-11-23
• Status Verified: 2023-12
• Study First Submitted QC: 2023-12-18
• Last Update Submitted: 2023-12-18
• Study First Posted: 2023-12-20
• Last Update Posted: 2023-12-20
• Study Start: 2024-01-01
• Primary Completion: 2025-01-01
• Study Completion: 2027-01-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 165

Inclusion Criteria

• Patients aged 40 years or above, presenting at the Emergency Department of the University Medical Center Hamburg-Eppendorf with a suspected acute ischemic stroke and a relevant neurological deficit (NIHSS score > 4).

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Exclusion Criteria

• A causal differential diagnosis for the acute stroke syndrome with absent intracranial vessel occlusion.
• No correlation for the patients' symptoms in the cranial CTA (no vessel obstruction).

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Cardiac Computed Tomography Angiography	Cardiac Computed Tomography Angiography	Patients with acute ischemic stroke who receive cardiac computed tomography angiography as part of the routine diagnostic work-up of acute ischemic stroke.

Primary Outcome Measures

Name	Time	Method
Diagnosis of therapy-relevant CAD and concomitant cardiac findings resulting in new therapeutic measurements.	1 day at hospital discharge	Number of (newly) prescribed medications (e.g., anticoagulants), cardiac diagnostics/interventions/planned interventions, clinical status (NIHSS, mRs).

Secondary Outcome Measures

Name	Time	Method
The rate of adverse cardiovascular events (MACE).	90 and 365 days	rate of major adverse cardiovascular events (MACE).