Evaluation of 4D Magnetic Resonance Angiography (K-t Blast) of Supraortic Vessels in Acute Ischemic Stroke Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 92
- 试验地点
- 1
- 主要终点
- Images quality for each cervical and intracranial arteries
研究概览
简要总结
The Magnetic Resonance angiography (MRA) of supraaortic vessels is essential for the etiologic of stroke. However, the techniques usually used provide only static evaluation (degree of stenosis, occlusion) but not dynamic. An ultra-fast 3D MRA originally developed for the cardiac imaging, k-t blast (Broad-use Linear Acquisition Speed-up Technique) could be used to review the supraaortic vessels. This MRA offers the following advantages: short acquisition time, wide spatial coverage (of the thoracic aorta to the distal encephalic arteries), 3D spatial resolution and high temporal resolution. These qualities are even more optimal with a high magnetic field (3T). The high temporal resolution is interesting because it provides to repeat a volume every eight seconds and thus to have a dynamic evaluation of vascular filling and to assess the vascular supply of the infarcted territory. This sequence is classified as a 4D MRA.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Men and women over 18 years
- •Eligibility for intravenous thrombolytic treatment (National Institute of Neurological Disorders and Stroke criteria)
- •Permanent ischemic stroke confirm with encephalic MRI (Magnetic Resonance Imaging)
- •Patient able of accepting protocol information
- •Patient who received information about the protocol and had not expressed its opposition to participate
排除标准
- •Pacemaker
- •Surgical ferromagnetic clips
- •Cochlear implants
- •Intraocular metallic foreign body
- •Iron implants or objects likely to concentrate the Radio Frequency field
- •Claustrophobia
- •Known intolerance to contrast media (DOTAREM)
- •Pregnant women (Beta Human Chorionic gonadotrophin performed for biological assessment of thrombolysis)
- •Patient with severe kidney with Glomerular Filtration rate < 30 ml/min
- •Persons subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty
结局指标
主要结局
Images quality for each cervical and intracranial arteries
时间窗: 6 months
次要结局
- Quantification of carotid stenosis with NASCET classification(6 months)
- Study of dynamic vascular consequences of carotid stenosis(6 months)