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Clinical Trials/ACTRN12609001087246
ACTRN12609001087246
Completed
未知

A randomised controlled trial to compare the incidence of bleeding events following prophylactic versus no prophylactic platelet transfusions in patients with haematological malignancies

ational Health Service Blood & Transplant0 sites600 target enrollmentDecember 18, 2009
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ConditionsHaematological malignanciesBlood - Haematological diseasesCancer - Other cancer types

Overview

Phase
未知
Intervention
Not specified
Conditions
Haematological malignancies
Sponsor
ational Health Service Blood & Transplant
Enrollment
600
Status
Completed
Last Updated
6 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
December 18, 2009
End Date
TBD
Last Updated
6 years ago
Study Type
Interventional
Sex
All

Investigators

Sponsor
ational Health Service Blood & Transplant

Eligibility Criteria

Inclusion Criteria

  • •Patients are eligible for this trial if:
  • •1\. They are aged 16 years or over
  • •2\. They have a confirmed diagnosis of a haematological malignancy
  • •3\. They have received or are going to receive myelosuppressive chemotherapy on this hospital admission with or without haematopoietic stem cell support (this includes patients undergoing haematopoietic stem cell transplantation \- autologous or allogeneic)
  • •4\. They are thrombocytopenic or expected to become thrombocytopenic with a platelet count of less than 50 x 10e9/L for at least 5 days
  • •5\. They are able to comply with treatment and monitoring

Exclusion Criteria

  • •Patients are not eligible for this trial if:
  • •1\. They have had a WHO Grade 3 or 4 bleed during any stage of their treatment to date
  • •2\. During the current admission, they have experienced or are currently experiencing a WHO Grade 2 or greater bleed
  • •3\. They have any inherited clotting disorder (e.g. haemophilia)
  • •4\. They need to remain on regular aspirin (or related drugs), or will require therapeutic doses of anticoagulants (e.g. heparin), during the whole period of thrombocytopenia
  • •5\. They have acute promyelocytic leukaemia and undergoing induction chemotherapy
  • •6\. They have known human leukocyte antigen (HLA) antibodies
  • •7\. They are pregnant
  • •8\. They have previously been randomised in this trial at any stage of their treatment

Outcomes

Primary Outcomes

Not specified

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