Higher Exhaled Nitric Oxide (NO) is Associated With Intraoperative Bronchospasm
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 31
- 试验地点
- 1
- 主要终点
- Exhaled nitric oxide in parts per billion
研究概览
简要总结
Intraoperative bronchospasm challenges anesthesia's safety. This study aims to investigate high concentration of exhaled nitric oxide as a marker of intraoperative bronchospasm.
详细描述
Previous studies in asthmatic patients suggested that exhaled nitric oxide may represent a noninvasive measure for airway inflammation. Anesthesia information forms from 1999 throughout 2004 were revised (n=146.358). Bronchospasm occurrence appeared registered on 863 forms. From those, nine were identified as non-asthmatics patients (Bronchospasm group). Also, 12 asthmatics constituted one additional group (Asthma group) and 10 subjects with no previous airway disease or symptoms (Control group). All subjects were submitted to Exhaled nitric oxide measurements (parts/billion), spirometry and induced sputum.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 16 Years 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients with no systemic disease and registered bronchospasm during anesthesia induction
排除标准
- •hypertension, COPD, diabetes, pregnancy
结局指标
主要结局
Exhaled nitric oxide in parts per billion
时间窗: one to six months after surgery
次要结局
- Eosinophils concentration within sputum sample, pulmonary function tests(one to six months after surgery)