Comparison Of Oral Health Status, Dental Caries Experience, Salivary Sialic Acid and Salivary Total Antioxidant Capacity in Thalassemic Children And Non Thalassemic Children.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- The Thalassemic patients and their parents are preoccupied with their life-threatening problems arising from the disease and often neglecting the basic preventive dental care. This study would help the patients to take proper care of their oral hygiene as neglection of this may add to existing complications Relation between salivary biomarkers and oral health status in Thalassemic children will help us in preventive dental treatment
研究概览
简要总结
The dissertation titled "Comparison of Oral Health Status, Dental Caries Experience, Salivary Sialic Acid and Salivary Total Antioxidant Capacity in Thalassemic Children and Non-Thalassemic Children" by Dr. Rutika Rajkumar Gawand, a postgraduate student in the Department of Pediatric and Preventive Dentistry at Rural Dental College, Loni, aims to assess and compare various oral health parameters and salivary biomarkers between children diagnosed with thalassemia and their healthy counterparts. Thalassemia is an inherited blood disorder that causes defective hemoglobin synthesis, leading to chronic anemia and systemic complications. In pediatric patients, the disease often manifests with oral and craniofacial abnormalities, including maxillary enlargement, malocclusion, and a higher risk of dental caries. These complications are often exacerbated by altered salivary composition and reduced oral hygiene maintenance.
This analytical case-control study will include 80 children aged 5 to 12 years—40 thalassemic and 40 non-thalassemic healthy children. The study will be conducted over two years within the facilities of the Department of Pediatric and Preventive Dentistry, the Department of Pediatrics, and the College of Biosciences and Technology, all under the Pravara Institute of Medical Sciences, Loni. The research objectives focus on evaluating and comparing oral hygiene status, caries experience, and key salivary biomarkers such as flow rate, pH, sialic acid levels, and total antioxidant capacity using non-invasive methods. These biomarkers will be assessed through spectrophotometric and pH-based analyses.
The study is based on the hypothesis that thalassemic children exhibit poorer oral health, increased dental caries, and altered salivary composition in comparison to healthy children. The results are expected to highlight the significance of incorporating oral health surveillance and preventive care into the routine management of thalassemic patients. The non-invasive nature of salivary diagnostics provides an efficient and safe means for early detection of oral health risks in medically compromised children. Through this study, the investigator aims to bridge the gap in understanding the oral-systemic link in thalassemia and emphasize the need for integrated dental care approaches in pediatric hematology.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 5.00 Year(s) 至 12.00 Year(s)（—）
- 性别
- All
入选标准
- •Non Thalassemic diagnosed children in age group of 5 to 12 years Children whose guardians are providing informed consent.
排除标准
- ••Presence of other systemic disease/s.
- ••Patient with cognitive impairment.
结局指标
主要结局
The Thalassemic patients and their parents are preoccupied with their life-threatening problems arising from the disease and often neglecting the basic preventive dental care. This study would help the patients to take proper care of their oral hygiene as neglection of this may add to existing complications Relation between salivary biomarkers and oral health status in Thalassemic children will help us in preventive dental treatment
时间窗: Thalassemic children and their parents often overlook oral health due to the burden of systemic illness. This study assesses the relationship between salivary biomarkers and oral health status to highlight the need for preventive dental care. The primary outcome—correlation between salivary biomarkers and oral health indicators—will be assessed at baseline, 4 weeks, and 8 weeks to guide early intervention strategies.
次要结局
- This study explores how thalassemia affects oral health & salivary composition. Primary outcomes (biomarker–oral health correlation) will be assessed at baseline, 4 weeks, & 8 weeks. Secondary outcomes include changes in individual parameters over time, aiding in preventive care & screening in thalassemic children.(This study explores how thalassemia affects oral health & salivary composition. Primary outcomes (biomarker–oral health correlation) will be assessed at baseline, 4 weeks, & 8 weeks. Secondary outcomes include changes in individual parameters over time, aiding in preventive care & screening in thalassemic children.)