Distinction of Cone Outer Segment Tips by Spectral-Domain Optical Coherence Tomography in Normal Eyes
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Kyorin University
- Enrollment
- 37
- Locations
- 1
- Primary Endpoint
- Microstructural analysis by Spectral domain optical coherence tomography
Study Overview
Brief Summary
The aim of this study is to investigate the incidence and possible causes of obscured or disrupted cone outer segment tips line at fovea in spectral-domain optical coherence tomography images of normal eyes.
Detailed Description
Thirty-seven eyes of 37 individuals without eye diseases were included in this study. Optical Coherence Tomography (OCT) images were taken using Cirrus HD-OCT (Carl Zeiss Meditec) with 5 line raster and high-definition 5 line raster modes. Images with signal strength weaker than 5/10 were excluded. Distinction of COST line and the integrity of COST line, external limiting membrane, and the photoreceptor inner segment and outer segment junction at the fovea were recorded. Demographic data, refractive error of the eyes, signal strengths of the OCT images were acquired for analysis.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 20 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •individuals without eye diseases
Exclusion Criteria
- •individuals with eye diseases
Outcomes
Primary Outcomes
Microstructural analysis by Spectral domain optical coherence tomography
Time Frame: one year
SD-OCT images of 6 mm scans were taken using Cirrus HD-OCT (OCT 4000, Carl Zeiss Meditec, Dublin, CA) with 5 line raster (5LR) and high-definition 5 line raster (HD5LR) modes.
Secondary Outcomes
- Visual acuity(one year)
Investigators
Makoto Inoue
Associate professor
Kyorin University