The Prevalence of Pulmonary Hypertension, With or Without Right Ventricular Loading, in Patients With COVID-19 Who Are Being Treated With a Respirator in the Intensive Care Unit.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Attgeno AB
- 入组人数
- 67
- 试验地点
- 1
- 主要终点
- Prevalence
研究概览
简要总结
The virus infection Covid-19 fills our hospitals and intensive care departments in a very unique way and there is a lack of essential insight into the pathophysiology of the disease. As a result, very specific treatment options are missing. The US Medicines Agency (FDA) has in the last days given a general license for treatment with inhaled nitric oxide (iNO). Inhaled NO in Sweden (and Europe) is approved for the indication of pulmonary hypertension in adults.
However, no one has yet described the occurrence of pulmonary hypertension, with or without right ventricular loading, in the Covid-19 patients who become so seriously ill that they need to be treated at an IVA ward. Knowledge of this is, of course, a prerequisite for determining the need for pulmonary artery catheterization (PA catheter, Swan-Ganz catheter) and also to better understand whether iNO treatment or other forms of lung selective vasodilation therapy may be of benefit to this patient group.
详细描述
Demographics and data from study variables will be documented in paper CRFs at the investigational site.
- Demography
o Age, sex
- Covid-19 related variables
o COVID-19 diagnosis
- Concomitant diseases
o Comorbidity, previous and present
- Cardiovascular risk factors
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Men and women at least 18 years of age
- •Diagnosed with COVID-19 and is treated at an intensive care unit.
排除标准
- •Responsible investigator considers that co-morbidity is so pronounced that it does not allow reasonable interpretation of data.
- •Missing verified diagnosis of COVID-19
结局指标
主要结局
Prevalence
时间窗: Day 1
To determine the prevalence of pulmonary hypertension and right ventricular load in patients with COVID-19 treated in intensive care unit evaluated by routine echocardiography.
次要结局
未报告次要终点
