跳至主要内容
临床试验/NCT04459364
NCT04459364已完成不适用

The Prevalence of Pulmonary Hypertension, With or Without Right Ventricular Loading, in Patients With COVID-19 Who Are Being Treated With a Respirator in the Intensive Care Unit.

Attgeno AB1 个研究点 分布在 1 个国家目标入组 67 人开始时间: 2020年6月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
Attgeno AB
入组人数
67
试验地点
1
主要终点
Prevalence

研究概览

简要总结

The virus infection Covid-19 fills our hospitals and intensive care departments in a very unique way and there is a lack of essential insight into the pathophysiology of the disease. As a result, very specific treatment options are missing. The US Medicines Agency (FDA) has in the last days given a general license for treatment with inhaled nitric oxide (iNO). Inhaled NO in Sweden (and Europe) is approved for the indication of pulmonary hypertension in adults.

However, no one has yet described the occurrence of pulmonary hypertension, with or without right ventricular loading, in the Covid-19 patients who become so seriously ill that they need to be treated at an IVA ward. Knowledge of this is, of course, a prerequisite for determining the need for pulmonary artery catheterization (PA catheter, Swan-Ganz catheter) and also to better understand whether iNO treatment or other forms of lung selective vasodilation therapy may be of benefit to this patient group.

详细描述

Demographics and data from study variables will be documented in paper CRFs at the investigational site.

  • Demography

o Age, sex

  • Covid-19 related variables

o COVID-19 diagnosis

  • Concomitant diseases

o Comorbidity, previous and present

  • Cardiovascular risk factors

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Other

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Men and women at least 18 years of age
  • Diagnosed with COVID-19 and is treated at an intensive care unit.

排除标准

  • Responsible investigator considers that co-morbidity is so pronounced that it does not allow reasonable interpretation of data.
  • Missing verified diagnosis of COVID-19

结局指标

主要结局

Prevalence

时间窗: Day 1

To determine the prevalence of pulmonary hypertension and right ventricular load in patients with COVID-19 treated in intensive care unit evaluated by routine echocardiography.

次要结局

未报告次要终点

研究者

发起方
Attgeno AB
申办方类型
Industry
责任方
Sponsor

研究点 (1)

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