Evaluation of ozone therapy in endodontic treatment of teeth with pulpal diseases

Not yet recruiting

Conditions: Necrosis of pulp,

Registration Number: CTRI/2021/03/032107

Lead Sponsor: Pacific dental college and hospital

Brief Summary: | |

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|***Need for the study:***

The success of endodontic treatment is highly related to the elimination or reduction of post-endodontic pain, many clinical studies have reported varying degrees of pain, ranging from 25 to 40%. Postoperative pains in patient undergoing root canal treatment is an undesirable complication in dental practice for both patient and dentist. The agent that triggers these events may have different origins, such as physic, chemical or microbiological; however, the latter seems to be the main cause of postoperative pain. The intensity of the inflammatory reaction can be influenced by several factors such as the degree of existing pathological changes in the periapical region, presence of certain bacterial species in the root canal.

Current literature on number of visits for root canal treatment provides conflicting opinions and recommendations. However, single-visit root canal treatment has become a common practice and offers several advantages, including decreased number of operative procedures, less time consuming, more economical for busy patients and no risk of inter-appointment leakage through temporary restorations. The disadvantages of single visit procedures are also obvious as it eliminates some of the controls available in the multiple visit procedures, such as culturing to check the effectiveness of the biomechanical preparation. But with meticulously instrumentation and irrigation in a single-visit root canal treatment a better disinfection and pain management can be achieved.

In endodontics, root canal irrigation is an integral part of preparation, which plays an important role in disinfection and removal of the debridement. The ideal irrigant should be strongly antimicrobial, able to dissolve the necrotic tissues, the remaining organic tissues, and be non-toxic to the periapical tissues if extruded through the apex. Not only irrigation solution but also the irrigation technique plays a crucial role in successful endodontic treatment. Therefore, newer irrigation solutions and techniques have to be tested to achieve this goal.

One such new generation of the disinfectant agents is ozone; a powerful oxidizing agent used to eliminate bacteria in root canals. Recent investigations of aqueous ozone have indicated that it is a powerful antimicrobial agent against oral pathogens and even resistant microorganisms too. One of the crucial properties of aqueous ozone is its non toxicity to oral cells in vitro than all other known antiseptics. However, the most important disadvantage of aqueous ozone is its unstable concentration in a long time. Consequently, aqueous ozone should be used as soon as possible after obtaining the ozone generator.

Irrigant exchange can be further improved in a number of ways, including pressure alteration, sonics, and ultrasonics. The simplest is manual dynamic agitation technique in which the obturating gutta-percha cone is pumped up and down in the canal. The literature is scarce on studies that evaluate whether efficacy of Ozone can be optimized by the use of the ultrasonic, pro-agitator tip system (PATS) or manual dynamic agitation.

Hence, the present study will aim to evaluate and compare the post-treatment pain after single-visit endodontics with three different Ozone application techniques (manual and ultrasonic and pro agitator tip system (PATS).

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 120

Inclusion Criteria

1.Patients will be selected at random, irrespective of age, sex, caste, religion, etiology and socioeconomic status .
2.Patients with good general health.
3.Patients readily available for follow up.
4.Patient willing to give consent for the study.
5.Patientâ€™s teeth with necrotic pulps and apical periodontitis.
(Primary/ Secondary endodontic treatment).
6.Presence of sufficient coronal tooth structure for rubber dam isolation.
7.Teeth with sound periodontal apparatus will be included in the study.

Exclusion Criteria

1.Patients with any systemic diseases, immune-compromised patients.
2.Patients allergic to ozone, recent myocardial infarction, acute alcohol intoxication, active bleeding, uncontrolled hyperthyroidism, thrombocytopenia, Glucose 6 phosphatase deficiency (Contraindications of ozone therapy).
3.Patients on analgesics or antibiotics five days prior to the clinical procedure.
4.Patients unwilling for follow up visits.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain assessment following Ozone irrigation in endodontic treatment of single rooted teeth	0 hours,6 hours, 12 hours, 24 hours , 48 hours, and 7 days

Secondary Outcome Measures

Name	Time	Method
Pain assessment following Ozone irrigation in endodontic treatment of single rooted teeth	0 hours,6 hours, 12 hours, 24 hours , 48 hours, and 7 days

Trial Locations

Locations (1): PACIFIC DENTAL COLEGE AND HOSPITAL
🇮🇳
Udaipur, RAJASTHAN, India
PACIFIC DENTAL COLEGE AND HOSPITAL
🇮🇳Udaipur, RAJASTHAN, India
DR NIDHI SINHA
Principal investigator
8619423478
dr.nidhi.sinha@gmail.com